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cyclic amp/seizures
Veza se sprema u međuspremnik
Stranica 1 iz 98 rezultatima
Electroconvulsive seizure increases the expression of CREM (cyclic AMP response element modulator) and ICER (inducible cyclic AMP early repressor) in rat brain.
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Rapid expression of ICER (inducible cyclic AMP early repressor), an inducible member of the CREM (cyclic AMP response element modulator) family of transcription factors, has been reported in neuroendocrine tissues and cell lines, but not in brain. In the present study, we demonstrate that acute
Cyclic AMP derivatives injected into the inferior colliculus induce audiogenic seizure-like phenomena in normal rats.
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Microinjection of 10 micrograms of either dibutyryl cyclic AMP or 8-bromo-cyclic AMP into the inferior colliculus of normal rats induced audiogenic seizure-like phenomena, which were intensified by sound stimulation. Microinjection of either cyclic AMP derivatives into areas surrounding the inferior
Hypoglycemia-induced seizures reduce cyclic AMP response element binding protein levels in the rat hippocampus.
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Cyclic AMP response element binding protein (CREB) is a transcription factor that has been implicated in the activation of protein synthesis required for long-term memory. Since memory deficits are manifest following seizure, we undertook the present study to investigate the effects of
Characterization of absence seizure-dependent cyclic AMP responsive element-and activator protein 1 DNA-binding activities in lethargic (lh/lh) mice.
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The characterized nuclear cyclic AMP responsive element (CRE)- and activator protein 1 (AP-1) DNA-binding activities in various brain regions of lethargic (lh/lh) mice, a genetic model of absence seizures. Gel-shift assays showed that nuclear CRE- and AP-1 DNA-binding activities in the thalamus and
Inositol trisphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures.
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The mechanism of action of lithium, the primary treatment for bipolar affective disorder, is unknown but may involve inhibition of second messenger production in the brain. Therefore, the concentrations of three second messengers, inositol 1,4,5 trisphosphate (Ins 1,4,5P3), cyclic adenosine
Effect of convulsions and anticonvulsive drugs on cerebrospinal fluid cyclic AMP in rabbits.
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Cyclic adenosine 3',5'-monophosphate (cAMP) concentration and aspartate amino transferase (ASAT or GOT) activity were measured from cerebrospinal fluid (CSF) of rabbits before and after electrically induced convulsions. The convulsions caused a significant increase in CSF cAMP concentration. The
Effects of gaba, gabob and some anticonvulsant drugs on dibutyryl cyclic AMP evoked seizures.
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The present experiments were undertaken to study the possible effects of Gaba, Gabob, phenobarbitone, diphenylhydantoin, and diazepam given systemically on convulsant activity evoked in chicks by intrahypothalamic injection of dibutyryl cyclic AMP (cAMP). Diphenylhydantoin and phenobarbitone
Cyclic GMP and cyclic AMP in the cerebral cortex of mice during seizures induced by 3-mercaptopropionic acid: effects of anticonvulsant agents.
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The onset of clonic seizures induced by 3-mercaptopropionic acid (MP) was associated with an approximately 200% increase of cAMP and a 70% elevation of cGMP in the mouse cerebral cortex. There was a further rise of both nucleotides during the subsequent tonic phase of convulsions; cAMP levels
Role of cyclic AMP and intracellular calcium concentration in seizure activity.
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Reduced cyclic-AMP responsiveness in the colliculus inferior of audiogenic seizure-prone rats.
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Changes of cyclic AMP and phosphorylase a in mouse cerebral cortex during seizures induced by 3-mercaptopropionic acid.
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Pentylenetetrazole-induced seizure activity produces an increased release of calcium from endoplasmic reticulum by mediating cyclic AMP-dependent protein phosphorylation in rat cerebral cortex.
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1. To determine the involvement of the convulsant agent pentylenetetrazole (PTZ) in intracellular calcium release in neurons, its effect on stored calcium in the endoplasmic reticulum of rat cortical neurons was tested. 2. Intraperitoneal injection of PTZ caused marked release of calcium from the
Cerebral metabolic changes during and following fluorothyl-induced seizures in ventilated rats.
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The objective of the present study was to assess metabolic changes in the neocortex and hippocampus of well-oxygenated or moderately hypoxic rats in which fluorothyl-induced seizures were sustained for 5 or 20 min, or which were allowed recovery periods of 5, 15, or 45 min following cessation of
Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex.
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The influence of chronic administration of antidepressants on cyclic AMP-dependent protein kinase activity was examined in rat frontal cortex. Chronic administration of imipramine, tranylcypromine, or electroconvulsive seizures decreased cyclic AMP-dependent protein kinase activity in soluble
[Cyclic AMP responsive element- and activator protein 1 DNA-binding activities in epilepsy model mice].
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Convulsive seizures caused by many different stimuli have been shown to induce activator protein-1 (AP-1) transcription factors in the brain, particularly in the hippocampus. Previous results from our laboratory demonstrated that thalamic and cerebral cortical AP-1 DNA- and cyclic AMP responsive
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