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2 rezultatima
Reduction of doxorubicin resistance by tetrandrine and dauricine in harringtonine-resistant human leukemia (HL60) cells.
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Prijava Registriraj se
OBJECTIVE
To study whether tetrandrine (Tet) and dauricine (Dau) can reduce doxorubicin (Dox) resistance in the harringtonine (Har)-resistant human leukemia cells.
METHODS
The drug cytotoxities were determined by counting cell numbers and colony formation. Cell cycle phases were assayed by flow
Bisbenzylisoquinoline alkaloids and P-glycoprotein function: A structure activity relationship study
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Prijava Registriraj se
Conflicts with the notion that specific substrate interactions were required in the control of reaction path in active transport systems, P-glycoprotein showed extraordinarily low specificity. Therefore, overexpression P-glycoprotein excluded a large number of anticancer agents from cancer cells,
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