fangchinoline/nekroza

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Effect of fangchinoline in murine models of multiple organ dysfunction syndrome and septic shock.

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OBJECTIVE To study the effect of the alkaloid fangchinoline on zymosan-induced multiple organ dysfunction syndrome (MODS) and Escherichia coli (E. coli)-induced septic shock. METHODS Male ICR mice were used. Macrophages were isolated from peritoneal cavity for in vitro study. METHODS Fangchinoline

Inhibitory effects of bisbenzylisoquinoline alkaloids on induction of proinflammatory cytokines, interleukin-1 and tumor necrosis factor-alpha.

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Bisbenzylisoquinoline alkaloids are known to affect immune responses as well as inflammatory responses, and have been used for the treatment of inflammatory symptoms in China. This study is aimed at elucidating the inhibitory effects of two alkaloids, fangchinoline and isotetrandrine, on the

Fangchinoline supplementation attenuates inflammatory markers in experimental rheumatoid arthritis-induced rats.

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The present study evaluated the anti-inflammatory activity of fangchinoline in rheumatoid arthritis-induced rats. Rats were grouped into sham (group I), rheumatoid arthritis (group II, control), fangchinoline (2 μM, group III), and fangchinoline (4 μM, group IV) groups. The serum levels of lipid

[Pharmacological Mechanisms of Boiogito and Bofutsushosan in Diabetes and Obesity Models].

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The antihyperglycemic activities of extracts of boiogito (BOT) and bofutsushosan (BTS) were investigated in streptozotocin-induced (STZ)-diabetic mice. BOT extract containing Stephania tetrandra S. MOORE root (stephania), has more potent antihyperglycemic activity than BOT extract containing

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