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2 rezultatima
A neutral CB1 receptor antagonist reduces weight gain in rat.
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Prijava Registriraj se
Cannabinoid (CB)1 receptor inverse agonists inhibit food intake in animals and humans but also potentiate emesis. It is not clear whether these effects result from inverse agonist properties or from the blockade of endogenous cannabinoid signaling. Here, we examine the effect of a neutral CB1
Excitation of area postrema neurons by transmitters, peptides, and cyclic nucleotides.
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Prijava Registriraj se
1. Multiple-barreled microelectrodes were used to record from neurons in the area postrema of anesthetized dogs and to test the responses of the neurons to a variety of substances in this structure, which is known to function as the chemoceptive trigger zone for emesis. 2. The neurons in area
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