giant/skopolamin

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GABA receptors and prepulse inhibition of acoustic startle in mice and rats.

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The acoustic startle reflex is strongly inhibited by a moderate-intensity acoustic stimulus that precedes the startling stimulus by roughly 10-1000 ms (prepulse inhibition, PPI). At long interstimulus intervals (ISIs) of 100-1000 ms, PPI in rats is reduced by the muscarinic receptor antagonist

[Synaptic ion currents in muscle fibers of Drosophila melanogaster].

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The spontaneous excitatory junctional currents (e. j. c.'s) were recorded intracellulary using voltage clamp technique in experiments performed on the isolated cutaneo-muscle bag of larvae, early pupae stadium and adult fly Drosophila melanogaster. The fast miniature e. j. c.'s with mean amplitude

Effects of a centipede venom fraction on insect nervous system, a native Xenopus oocyte receptor and on an expressed Drosophila muscarinic receptor.

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Centipede venoms are complex protein mixtures; very few is known about their pharmacological actions. Application of a Scolopendra sp. venom fraction (SC1) on the cockroach giant axon induced an increase in the leak current correlated with a decrease in the membrane resistance, suggesting the

Cholinergic mechanism underlying prepulse inhibition of the startle response in rats.

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Startle responses are attenuated by prepulse inhibition (PPI), which is considered to reflect a sensorimotor gating mechanism and is impaired in patients suffering from schizophrenia. A midbrain circuit that mediates PPI in rats has been proposed and behavioral experiments have indicated an

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