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2 rezultatima
Grandinin down-regulates phosphorylation of epidermal growth factor receptor.
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OBJECTIVE
Grandinin (C(46)H(34)O(30)) is a compound found in Melaleuca quinquenervia leaves and in oaks. This study is to determine effects of grandinin on malignant lung cells and the related molecular mechanisms.
METHODS
Malignant cells were treated with grandinin with various concentrations. The
Polyphenols of Melaleuca quinquenervia leaves--pharmacological studies of grandinin.
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Four polyphenolic acid derivatives and three ellagitannins were isolated from the leaves of Melaleuca quinquenervia (Clav.) S. T. Blake for the first time. Their structures were elucidated as gallic acid (1), ellagic acid (2), 3-O-methylellagic acid (3), 3,4,3'-tri-O-methylellagic acid (4),
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