Ferulate compounds derived from extracts from the plant Commiphora wightii are used in compositions and methods for prevention and treatment of abnormal cell growth and proliferation in inflammation, neoplasia and cardiovascular disease.

Sabinsa Corporation

Sami Chemicals &amp; Extracts

Ltd.

Composition and method containing products extracted from Commiphora sp. for prevention and treatment of abnormal cell growth and proliferation in inflammation, neoplasia and cardiovascular disease

The subject invention pertains to supercritical carbon dioxide extracts of Commiphora mukul resin (guggul), which can be modified or not modified by some ethanol addition; methods for their production; and methods of use, such as inhibiting HMG-CoA reductase, inhibiting transformation of pre-adipocytes to adipocytes, inhibiting triglyceride storage, promoting insulin sensitivity in adipocytes, treatment of disorders (for example, hypercholesterolemia, hyperlipidemia, hyperglycemia, obesity, metabolic syndrome, cardiovascular disease, atherosclerotic heart disease, autoimmune disorder, insulin resistance, leptin resistance, arthritis, cell proliferation disorder, such as cancer and atherosclerosis; damaged skin, sores, cuts, rashes, bruises, dryness, burns, sunburn, radiation burn, and infection), and regulating or suppressing appetite.

guggul/rak

Composition and method containing products extracted from Commiphora sp. for prevention and treatment of abnormal cell growth and proliferation in inflammation, neoplasia and cardiovascular disease

Method for stimulating AMP-activated protein kinase

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