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Gap Junction Blockers: An Overview of their Effects on Induced Seizures in Animal Models.
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Prijava Registriraj se
BACKGROUND
Gap junctions are clusters of intercellular channels allowing the bidirectional pass of ions directly into the cytoplasm of adjacent cells. Electrical coupling mediated by gap junctions plays a role in the generation of highly synchronized electrical activity. The hypersynchronous
Modulation of burst frequency, duration, and amplitude in the zero-Ca(2+) model of epileptiform activity.
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Incubation of hippocampal slices in zero-Ca(2+) medium blocks synaptic transmission and results in spontaneous burst discharges. This seizure-like activity is characterized by negative shifts (bursts) in the extracellular field potential and a K(+) wave that propagates across the hippocampus. To
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