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13 rezultatima
Anti-cancer hydantoin compounds and methods
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BACKGROUND
Cancer is one of the leading causes of death in Americans. Drugs that can prevent or limit metastasis, growth, or invasive properties of cancer in mammals have the potential for life saving use in humans. Metastasis is one of the predominant factors in the mortality of cancer patients.
Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)
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FIELD OF THE INVENTION
The present invention relates generally to novel hydantoin derivatives as inhibitors of TNF-.alpha. converting enzyme (TACE), or matrix metalloproteinases (MMP) or a combination thereof, pharmaceutical compositions containing the same, and methods of using the same.
BACKGROUND
N-hydroxy bicyclic hydantoin carbamates as tools for identification of serine hydrolase targets
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BACKGROUND
Serine hydrolase inhibitors, which facilitate enzyme function assignment and are used to treat a range of human disorders, often act by an irreversible mechanism that involves covalent modification of the serine hydrolase catalytic nucleophile.
BRIEF SUMMARY OF THE INVENTION
This
Hydantoin compounds and methods of use thereof
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BACKGROUND OF THE INVENTION
This invention relates to hydantoin compounds and methods of use thereof, and more particularly this invention relates to novel hydantoin compounds which have anti-tumor activity against transplanted mouse tumor test systems.
The design of drugs which have potential
Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
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FIELD OF THE INVENTION
The present invention relates to hydantoins, thiohydantoins, dithiohydantoins, hydantoinimines and thiohydantoinimines compounds, methods of using such compounds in the treatment of androgen receptor-associated conditions, such as age-related diseases, for example, prostate
Substituted hydantoins
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FIELD OF THE INVENTION
The present invention relates to hydantoin derivatives and their use as inhibitors of the two protein kinases commonly known as MEK1 and MEK2 for the treatment of human diseases such as cancer. MEK is a commonly used abbreviation for MAP/ERK kinase which is in turn an
Substituted hydantoins
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FIELD OF THE INVENTION
The present invention relates to hydantoin derivatives and their use as inhibitors of the two protein kinases commonly known as MEK1 and MEK2 for the treatment of human diseases such as cancer. MEK is a commonly used abbreviation for MAP kinase/ERK kinase which is in turn an
Substituted hydantoins
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FIELD OF THE INVENTION
The present invention relates to hydantoin derivatives as inhibitors of the two protein kinases commonly known as MEK1 and MEK2 for the treatment of human diseases such as cancer. MEK is a commonly used abbreviation for MAP kinase/ERK kinase which is in turn an abbreviation
Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by VLA-4
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to compounds which inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4 and/or LPAM-1. This invention is also directed to pharmaceutical compositions comprising such compounds as well as to
Derivatives of hydantoins, thiohydantoins, pyrimidinediones and thioxopyrimidinones, their preparation processes and their use as medicaments
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The invention relates to new derivatives of hydantoins, thiohydantoins, pyrimidinediones and thioxopyrimidinones of general formula (I) represented below, their preparation processes and their use as medicaments. These compounds have a good affinity with certain sub-types of somatostatin receptors
Derivatives of hydantoins, thiohydantoins, pyrimidinediones and thioxopyrimidinones, their preparation processes and their use as medicaments
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The invention relates to new derivatives of hydantoins, thiohydantoins, pyrimidinediones and thioxopyrimidinones of general formula (I) represented below, their preparation processes and their use as medicaments. These compounds have a good affinity with certain sub-types of somatostatin receptors
Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
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INTRODUCTION
Technical Field
The field of this invention is compounds and their use in the treatment of prostate cancer and hyper-androgenic syndromes including alopecia, hirsutism and acne vulgaris.
Background
The existence of a number of pathologic syndromes depends on androgen hormones. Thus,
Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes
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TECHNICAL FIELD
The field of this invention is compounds and their use in the treatment of prostate cancer and hyper-androgenic syndromes including alopecia, hirsutism and acne vulgaris.
BACKGROUND
The existence of a number of pathologic syndromes depends on androgen hormones. Thus, growth of
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