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12 rezultatima
Spiro-hydantoin compounds useful as anti-inflammatory agents
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FIELD OF THE INVENTION
The present invention relates to spiro-hydantoin compounds, pharmaceutical compositions containing them, and methods of using such compounds in treating inflammatory or immune disease.
BACKGROUND OF THE INVENTION
Cells adhere to other cells and to substrates through specific,
Spiro-hydantoin compounds useful as anti-inflammatory agents
Samo registrirani korisnici mogu prevoditi članke
Prijava Registriraj se
FIELD OF THE INVENTION
The present invention relates to spiro-hydantoin compounds, pharmaceutical compositions containing them, and methods of using such compounds in treating inflammatory or immune disease.
BACKGROUND OF THE INVENTION
Cells adhere to other cells and to substrates through specific,
Pyridyl-substituted spiro-hydantoin compounds and use thereof
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FIELD OF THE INVENTION
The present invention provides a class of pyridyl-substituted spiro-hydantoin compounds having unexpectedly desirable pharmacological characteristics. Pharmaceutical compositions and methods of treating anti-inflammatory and/or immune diseases with the pyridyl-substituted
Urea hydantoin derivatives as formyl peptide modulators
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FIELD OF THE INVENTION
The present invention relates to urea hydantoin derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use as pharmaceuticals as modulators of the N-formyl peptide 2 receptor (FPR2). The invention relates specifically to the use of
Crystalline forms and process for preparing spiro-hydantoin compounds
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FIELD OF INVENTION
The present invention relates to a process for preparing spiro-hydantoin compounds and substituted spiro-hydantoin compounds. Also provided are crystalline forms of the substituted spiro-hydantoin compound, 5-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,-
N-hydroxy bicyclic hydantoin carbamates as tools for identification of serine hydrolase targets
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BACKGROUND
Serine hydrolase inhibitors, which facilitate enzyme function assignment and are used to treat a range of human disorders, often act by an irreversible mechanism that involves covalent modification of the serine hydrolase catalytic nucleophile.
BRIEF SUMMARY OF THE INVENTION
This
Substituted hydantoins
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FIELD OF THE INVENTION
The present invention relates to hydantoin derivatives and their use as inhibitors of the two protein kinases commonly known as MEK1 and MEK2 for the treatment of human diseases such as cancer. MEK is a commonly used abbreviation for MAP/ERK kinase which is in turn an
Substituted hydantoins
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Prijava Registriraj se
FIELD OF THE INVENTION
The present invention relates to hydantoin derivatives and their use as inhibitors of the two protein kinases commonly known as MEK1 and MEK2 for the treatment of human diseases such as cancer. MEK is a commonly used abbreviation for MAP kinase/ERK kinase which is in turn an
Substituted hydantoins
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Prijava Registriraj se
FIELD OF THE INVENTION
The present invention relates to hydantoin derivatives as inhibitors of the two protein kinases commonly known as MEK1 and MEK2 for the treatment of human diseases such as cancer. MEK is a commonly used abbreviation for MAP kinase/ERK kinase which is in turn an abbreviation
Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by VLA-4
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to compounds which inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4 and/or LPAM-1. This invention is also directed to pharmaceutical compositions comprising such compounds as well as to
Hydantoin derivatives as inhibitors of leucocyte adhesion and as VLA-4 antagonists
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The present invention relates to compounds of the formula I ##STR2##
as inhibitors of the adhesion and migration of leucocytes and/or as antagonists of the adhesion receptor VLA-4 which belongs to the group of integrins. The invention relates to the use of compounds of the formula I and of
Eliminating agent for activated oxygen and free radicals
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FIELD OF THE INVENTION
The present invention relates to agents for eliminating active oxygen and free radicals containing a hydantoin derivative or a pharmaceutically acceptable salt thereof as an effective component. The reduction and elimination of free radicals and activated oxygen in living
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