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linamarase/glioma
Veza se sprema u međuspremnik
3 rezultatima
Toxicity and delivery methods for the linamarase/linamarin/glucose oxidase system, when used against human glioma tumors implanted in the brain of nude rats.
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Prijava Registriraj se
Glioblastoma multiforme (GBM) is one of the deadliest forms of cancer, with an average survival time of approximately 1year despite aggressive surgery, radiotherapy and chemotherapy. Here, we report a preclinical study by which the two main energy pathways of the tumor cells, oxidative
Glioma regression in vitro and in vivo by a suicide combined treatment.
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Prijava Registriraj se
We present here a suicide therapy against malignant gliomas based on the transfer to tumor cells of a gene encoding a beta-glucosidase, linamarase (lis), which in the presence of the innocuous substrate linamarin (lin) produces cyanide, blocking the mitochondrial respiratory chain. Dog glioma cells
Successful use of a plant gene in the treatment of cancer in vivo.
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Prijava Registriraj se
A new strategy for cancer gene therapy has been developed using a plant gene which encodes the enzyme, linamarase, that hydrolyzes the cyanogenic glucoside substrate, linamarin, into glucose, acetone and cyanide. Retroviral vectors that carry linamarase as a potential killer-suicide gene cause a
Najkompletnija baza ljekovitog bilja potpomognuta znanošću
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