Continuous rocuronium infusion will be used to induce a deep surgical block with post tetanic twitch count of max 2. Rocuronium loading dose = 1.0 mg/kg, followed by 0.6-1.0 mg/kg per hour.

A normal block will be induced by an atracurium bolus dose followed by a mivacurium infusion to induce a train of four count of 1-2.

Moderate/Normal Surgical Block

Deep Surgical Block

Total

Sex: Female, Male

Region of Enrollment

During the procedure, the surgical condition will be scored by the surgeon using a 5-point surgical rating scale. In order to reduce variability in the surgical rating all surgeries will be performed by one single surgeon. The rating scale will be a 5-point ordinal scale ranging from 1 = poor condition to 5 = optimal surgical conditions. The surgeon will score the condition at 15 minute intervals. In case of a sudden change in surgical conditions additional scores will be added to the case record form. If conditions are poor (score 1 or 2), muscle relaxation will be increased, a score of 1 will be used.
In each subject the scores over time were averaged and a comparison between treatments was performed using a t-test

Surgical Rating Scale

In the recovery room the respiratory rate will be measured continuously using the Respir8 respiratory rate monitor. The data will be recorded on the CRF at 15 min intervals.
Breathing rate units are "number of breaths" as measured in 1 min.
Comparison by t-test: NS between treatments

Breathing

Using a 10 cm visual analogue score pain relief score will be measured. 0 = no pain 10 = most severe pain
No statistical analysis was performed!

Post-operative Pain

Using a 5-point sedation scale, sedation levels will be obtained throughout the postoperative period.
0 = wide awake 5= severely sedated, The sedation data were averaged over time.

Postoperative Sedation Score

Using a yes - no questionnaire, the patients will be asked whether they are nauseated or not or whether they vomited. In fact yes indicates the nr of participants.
No statistical analysis was performed.

Nausea and Vomiting

Overall Study

Dr. Albert Dahan

Prostate Hypertrophy

Renal Disease

The surgical block will be varied by either induction of a deep block (via rocuronium infusion) or a moderate/normal block (using atracurium/mivacurium infusion)

Surgical block (rocuronium; atracurium/mivacurium)

A surgical block will be induced by infusion of either rocuronium (deep block) or atracurium/mivacurium (normal/moderate block)

Website of the hospital in which the study will be performed

Leiden University Medical Center

Effect of Deep BLock on Intraoperative Surgical Conditions

Effect of Deep BLock on Intraoperative Surgical Conditions, Perioperative Hemodynamic Status and Respiratory Parameters Following Reversal With Sugammadex in Patients Undergoing Laparoscopic Renal and Prostate Surgery.

muscarine/povraćanje

Effect of Deep BLock on Intraoperative Surgical Conditions

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