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3 rezultatima
Stimulation of fibroblast biosynthetic activity by serum of patients with pretibial myxedema.
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Prijava Registriraj se
Skin fibroblasts from the shoulder and lower extremities of normal individuals, as well as from patients with pretibial myxedema (PTM) were grown in culture. When cells reached the monolayer stage, they were labeled with 3H-glucosamine and tested for hyaluronic acid synthesis in the presence of
Elastase inhibitory activity in serum of patients with thyroid dysfunction.
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Prijava Registriraj se
Dermal elastic fiber fragmentation and decreased fiber density are characteristic cutaneous abnormalities in myxedema. We therefore evaluated elastase inhibitory activity in serum in thyroid dysfunctional states by measuring the protease inhibitor alpha 1-antitrypsin (A-1-AT), as well as by directly
Molecular basis for the autoreactivity against thyroid stimulating hormone receptor.
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Prijava Registriraj se
The present report identifies an important immunogenic region of the TSH receptor and determinants on the TSH receptor for the two types of autoantibodies seen in hyperthyroid Graves' disease and hypothyroid idiopathic myxedema, TSAbs and TSBAbs, respectively. The immunogenic domain with no
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