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oncogene addiction/hypoxia
Veza se sprema u međuspremnik
5 rezultatima
The Leukemic Stem Cell Niche: Adaptation to "Hypoxia" versus Oncogene Addiction.
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Prijava Registriraj se
Previous studies based on low oxygen concentrations in the incubation atmosphere revealed that metabolic factors govern the maintenance of normal hematopoietic or leukemic stem cells (HSC and LSC). The physiological oxygen concentration in tissues ranges between 0.1 and 5.0%. Stem cell niches (SCN)
Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia.
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Prijava Registriraj se
Oncogenic addiction to the Fms-like tyrosine kinase 3 (FLT3) is a hallmark of acute myeloid leukemia (AML) that harbors the FLT3-internal tandem duplication (FLT3-ITD) mutation. While FLT3 inhibitors like sorafenib show initial therapeutic efficacy, resistance rapidly develops through mechanisms
Conserved features of cancer cells define their sensitivity to HAMLET-induced death; c-Myc and glycolysis.
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HAMLET is the first member of a new family of tumoricidal protein-lipid complexes that kill cancer cells broadly, while sparing healthy, differentiated cells. Many and diverse tumor cell types are sensitive to the lethal effect, suggesting that HAMLET identifies and activates conserved death
Constitutive or Induced HIF-2 Addiction is Involved in Resistance to Anti-EGFR Treatment and Radiation Therapy in HNSCC.
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Prijava Registriraj se
BACKGROUND
management of head and neck squamous cell carcinomas (HNSCC) include anti-Epidermal Growth Factor Receptor (EGFR) antibodies and radiotherapy, but resistance emerges in most patients. RAS mutations lead to primary resistance to EGFR blockade in metastaticRole of the unfolded protein response in tumor cell characteristics and cancer outcome.
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Prijava Registriraj se
In the present review, we discuss the possible role of the unfolded protein response (UPR) in the acquisition of tumor cell characteristics and in the prognosis of cancer outcome, which could assist and contribute to the development of more promising therapeutic strategies.
Accumulating evidence
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