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phosphodiesterase/upala
Veza se sprema u međuspremnik
Stranica 1 iz 176 rezultatima
Combination of HMG-CoA reductase inhibitors with phosphodiesterase 4 inhibitors for the treatment of inflammatory pulmonary diseases
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TECHNICAL FIELD
The present invention relates to the combination of certain known therapeutic compounds for therapeutic purposes. The substances used in the combinations according to the invention are known active agents from the phosphodiesterase 4 (PDE4) inhibitor class and active agents from the
Combination of anticholinergics, .beta.2-adrenoceptor agonists, antileukotrienes (leukotriene receptor antagonists), glucocorticoids and/or phosphodiesterase 4 inhibitors for the treatment of inflammatory diseases
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The invention relates to novel combinations based on anticholinergics, .beta..sub.2-adrenoceptor agonists, PDE 4 Inhibitors, glucocorticoids, and leukotriene-receptor antagonists, process for their production and their use for the treatment of inflammatory diseases, preferably respiratory diseases
Oligonucleotide compositions and methods for treating disease including inflammatory conditions
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FIELD OF THE INVENTION
The invention relates to methods, reagents and compositions of use for antisense oligonucleotide-based therapy. In particular, the invention relates the application of antisense oligonucleotide-based therapy in the treatment of disease associated with reduced cAMP in a patient
Oligonucleotide compositions and methods for treating disease including inflammatory conditions
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FIELD OF THE INVENTION
The invention relates to methods, reagents and compositions of use for antisense oligonucleotide-based therapy. In particular, the invention relates the application of antisense oligonucleotide-based therapy in the treatment of disease associated with reduced cAMP in a patient
Oligonucleotide compositions and methods for treating disease including inflammatory conditions
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FIELD OF THE INVENTION
The invention relates to methods, reagents and compositions of use for antisense oligonucleotide-based therapy. In particular, the invention relates the application of antisense oligonucleotide-based therapy in the treatment of disease associated with reduced cAMP in a patient
Oligonucleotides affecting expression of phosphodiesterases
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FIELD OF THE INVENTION
The invention relates to methods, reagents and compositions of use for antisense oligonucleotide-based therapy. In particular, the invention relates the application of antisense oligonucleotide-based therapy in the treatment of diseases associated with reduced cAMP in a
Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
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This invention relates to novel aryl oxime-carbamates and carbonates having bronchodilatory and anti-inflammatory activities and being useful in the treatment of asthma.
Asthma is a disease in which respiratory distress is produced as a result of airway narrowing. This narrowing is caused largely by
Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors
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FIELD OF THE INVENTION
The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors.
Compounds disclosed herein can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple
Pyrazolo[3,4-B]pyridine compounds, and their use as phosphodiesterase inhibitors
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This application claims the benefit of International Application No. PCT/EP2003/014867 filed 19 Dec. 2003.
The present invention relates to pyrazolopyridine compounds, processes for their preparation, intermediates usable in these processes, and pharmaceutical compositions containing the compounds.
Alkyne-aryl phosphodiesterase-4 inhibitors
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FIELD OF THE INVENTION
The present invention is directed to compounds that are alkyne-aryl substituted 1,8-naphthyridin-4(1H)-ones. In particular, this invention is directed to phenyl substituted 1,8-naphthyridin-4(1H)-ones which are phosphodiesterase-4 inhibitors wherein the phenyl group is at the
Inhibitors of phosphodiesterase type-IV
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FIELD OF INVENTION
The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary
Phosphodiesterase 4-inhibiting diazepinoindolones
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FIELD OF THE INVENTION
The present invention relates to new [1,4]diazepino[6,7,1-hi]indol-4-ones which are useful for the preparation of medicaments that enable complaints which are amenable to therapy by a phosphodiesterase 4 inhibitor to be treated. These medicaments are useful, in particular, as
Pyrrolopyrimidines as phosphodiesterase VII inhibitors
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The invention relates to compounds of the formula I
##STR00002## in which X is phenyl or Het, each of which is unsubstituted or monosubstituted or polysubstituted by R.sup.1 and/or R.sup.2, R.sup.1 and R.sup.2 are each, independently of one another, A, OH, OA, SA, SOA, SO.sub.2A, SO.sub.2NH.sub.2,
Substituted indazoles as inhibitors of phosphodiesterase type-IV
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FIELD OF THE INVENTION
The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV.
Compounds disclosed herein can be useful in the treatment of CNS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive
Thiazole derivatives as phosphodiesterase IV inhibitors
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The invention relates to compounds of the formula I
##STR00002## in which R.sup.1 and R.sup.2 are each, independently of one another, H, OH, OR.sup.8, --SR.sup.8, --SOR.sup.8, --SO.sub.2R.sup.8 or Hal, R.sup.1 and R.sup.2 together are alternatively --OCH.sub.2O-- or --OCH.sub.2CH.sub.2O--, R.sup.3
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