Participants randomized to the control group will receive diet and exercise counseling at baseline and 9 months. Participants will wear an ActivePAL for 7 days at baseline, 9 months, and 18 months without stimulation.

Participants randomized to the intervention will perform supervised aerobic, resistance and balance training twice weekly for 12 weeks, and weekly thereafter. Actigraphy-based counseling to reduce sedentary behavior will follow a similar taper. Daily text messages, "tweets", emails, and social media posts at random times during waking hours will be used to provide reminders and motivational messages. Participants will have 11 separate 7-day continuous ActivePAL training session incorporating vibrostimulatory feedback spread across the treatment period.

Diabetic Neuropathy

Standard Care Counseling

Supervised Exercise and Counseling

University of Kansas

University of Utah School of Medicine

Activity for Diabetic Polyneuropathy

Activity for Diabetic Polyneuropathy: the ADAPT Study

Virginia Commonwealth University

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

University of Utah

calcined magnesia 100 mg tablets once a day for 16 weeks

ezetimibe/simvastatin 10/20 mg tablets once a day for 16 weeks

rosuvastatin 20 mg tablets once a day for 16 weeks

Oxidative Stress

Diabetic Polyneuropathy

We ensured the patient took the drug at night before meals

calcined magnesia

Ezetimibe/simvastatin

Rosuvastatin

Cardiovascular Research Unit

Statins for Oxidative Stress and Mitochondrial Function in Diabetic Polyneuropathy

Ezetimibe/Simvastatin and Rosuvastatin for Oxidative Stress and Mitochondrial Function in Diabetic Polyneuropathy: a Randomized, Double Blinded, Placebo Controlled Clinical Trial

LPO was measured according to kit specifications (Oxford Biomedical Research Inc., FR12), 200 μL of serum where processed with a chromogen substance that reacts with malondialdehyde (MDA) and 4-hydroxy-alkenals (HNA), the absorbance measured at 586 nm, and results expressed in nmol/mL.

Previous deproteinization of the samples, we performed a colorimetric for determining the concentration of NO with 85 µL of serum (Nitric Oxide Assay Kit, User protocol 482650), with results expressed as pmol/mL.

Total antioxidant capacity (TAC) was realized with 200 µL of serum, to obtain values of mM equivalent of uric acid (Total Antioxidant Power Kit, No. 02090130, Oxford Biomedical Research®).

Symptoms referred by the patient as pain and discomfort

Neuropathic signs assessed by the physician through neurological techniques previously published by Dyck et. al.

Latency, duration, amplitude and motor nerve conduction velocity from fibula, tibial, median and ulnae nerves, and sensitivity parameters from sural, median and ulnae nerves, as required by the American Association of Electrodiagnostic Medicine.

polyneuropathies/triglyceride

Activity for Diabetic Polyneuropathy

Statins for Oxidative Stress and Mitochondrial Function in Diabetic Polyneuropathy

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