pulchellin/carpesium

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[Study on Chemical Constituents from Carpesium abrotanoides].

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OBJECTIVE To study the chemical constituents from Carpesium abrotanoides. METHODS Compounds were isolated and pu- rified by silica gel and Sephadex LH-20 column chromatography, their structures were determined by using spectroscopic analysis. RESULTS Ten compounds were isolated and identified as

[Simultaneous determination of five sesquiterpene lactones in Carpesium abrotanoides by HPLC].

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An HPLC method was established to simultaneously determine the five sesquiterpene lactones, carabrone, carabrol, 2-desoxy-4-epi-pulchellin, telekinand 11(13)-dehydroivaxillin in Carpesium abrotanoides. Samples were analyzed on a kromasil C18 column (4.6 mm x 250 mm, 5 µm); mobile phase: A was

Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.

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A new dimeric sesquiterpene, dicarabrol (1), together with three known sesquiterpenes, carabrol (2), 11(13)-dehydroivaxillin (3), and 2-desoxy-4-epi-pulchellin (4), were isolated from the whole plant of Carpesium abrotanoides L. Their structures were elucidated on the basis of spectroscopic

A natural compound derivative P-13 inhibits STAT3 signaling by covalently inhibiting Janus kinase 2.

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We investigated the function and molecular mechanisms of 2-desoxy-4β-propylcarbamate-pulchellin (P-13), a sesquiterpene lactone derivative of 2-desoxy-4-epi-pulchellin from the traditional Chinese medicinal herb Carpesium abrotanoides L, in regulating STAT3 signaling and cancer cell growth. We found

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