Volunteers will be randomised double blinded into 'Anthocyanins' groups(n=60 per group)and given twice daily two capsules of either 80 grams of Anthocyanins, which corresponds a mixture of fresh blue berries and blackcurrants.The total duration of this trial was 24wk.

A daily intake of 320mg Placebo to instead of treatment of Anthocyanins.

Insulin Resistance

Glucose Metabolism Disorders

Type 2 Diabetes

Lipid Metabolism Disorders

Anthocyanins capsules, which comprises different natural Anthocyanins purified from bilberries and blackcurrants

Anthocyanins

Placebo capsules is identically packaged.

Placebo

The effects of purified anthocyanins on dyslipidemia, oxidative status, and insulin sensitivity in patients with type 2 diabetes.

The effects of anthocyanin supplementation on insulin resistance and liver injury biomarkers in patients with NAFLD.

The supplementation of an anthocyanin mixture to hypercholesterolemic subjects for 24 weeks reduced serum levels of CRP, VCAM-1 and IL-1b, which involved the improvement of the lipid profile

Baiyun Street Hospital,Yuexiu District

Effect of Anthocyanins on Metabolic Profiles in Subjects With Pre-diabetes

Effect of Anthocyanins on Metabolic Profiles in Subjects With Pre-diabetes: A Randomized, Double-blind, Placebo-controlled Study

Total cholesterol,Triglycerides,HDL cholesterol,LDL cholesterol,Apolipoprotein A-I ,Apolipoprotein B

LiPing Yang

Sun Yat-sen University

Control: sugar matched (matched to currant sugar content) water with polycal
Blackcurrants (200grams) with polycal
Blackcurrants (200grams) with glucose
Greencurrants (200grams) with polycal Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The OGTT will be carried out with glucose as a simple carbohydrate load or polycal as a complex carbohydrate load.
Volunteers will be randomised into four groups (n=4 per group). One week wash out between treatments

Blackcurrants (200grams) with polycal
Blackcurrants (200grams) with glucose
Greencurrants ( 200grams) with polycal
Control: sugar matched (matched to currant sugar content) water with polycal
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The OGTT will be carried out with glucose as a simple carbohydrate load or polycal as a complex carbohydrate load as decribed above.
Volunteers will be randomised into four groups (n=4 per group). One week wash out between treatments

Blackcurrants (200grams) with glucose
Greencurrants (200grams) with polycal
Control: sugar matched (matched to currant sugar content) water with polycal
Blackcurrants (200grams) with polycal
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The OGTT will be carried out with glucose as a simple carbohydrate load or polycal as a complex carbohydrate load as decribed above
Volunteers will be randomised into four groups (n=4 per group). One week wash out between treatments

Greencurrants (200grams) with polycal
Control: sugar matched (matched to currant sugar content) water with polycal
Blackcurrants (200grams) with polycal
Blackcurrants (200grams) with glucose
Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The OGTT will be carried out with glucose as a simple carbohydrate load or polycal as a complex carbohydrate load as decribed above.
Volunteers will be randomised into four groups (n=4 per group). One week wash out between treatments.

Sixteen overweight/obese volunteers from the Aberdeen area will be recruited into a randomised controlled study. Volunteers will be randomised into four groups matched for BMI and age and given 200 grams of blackcurrants (which contain anthocyanins) or greencurrants (which naturally contain no anthocyanins), followed by an OGTT.
The consumption of the currants will be followed by an oral glucose tolerance test (OGTT) with Polycal (complex carbohydrate) or glucose (simple carbohydrate) as the carbohydrate load.
The equivalent carbohydrate load will be standardised across the groups

Blackcurrants with polycal OGTT

Greencurrants with polycal OGTT

Blackcurrants with glucose OGTT

Sugar matched water with polycal OGTT

University of Aberdeen Rowett Institute of Nutrition and Health

Effect of Soft Fruit on Postprandial Blood Glucose

University of Aberdeen

Grapes in the form of a Freeze-dried Whole Grape Powder. 60g freeze-dried whole grape powder with 296mg polyphenols per day for 4 weeks.

Grape Powder Placebo. 60g control food (matched for calories, low in polyphenols, and indistinguishable from active intervention) per day for 4 weeks.

Obesity

Inflammation

Cardiovascular Disease

Oxidative Stress

60g freeze-dried whole grape powder with 296mg polyphenols per day for 4 weeks.

Grape in the form of freeze-dried whole grape powder

60g control food (matched for calories, low in polyphenols, and indistinguishable from active intervention) per day for 4 weeks.

Grape powder placebo

Ragle Human Nutrition Center

The Effects Grapes on Health Indices

Pilot Study: The Effects of Whole Grapes on Markers of Health

High sensitivity C reactive protein, TNF-alpha, IL-1beta, lL-6. Assessed at time 0, 1, 3, 5 hours of acute meal challenge and in fasting samples at the end of the intervention.

Oxidized low density lipoprotein, urinary F2-isoprostane.

Blood pressure, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, ESelectin.

Total cholesterol, low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglyceride level, apolipoproteinA1, apolipoproteinB100.

TLR4, SOCS-3, NADPH oxidase subunit p47phox, Nrf-2, p50 subunit, IL-1β, MMP-9, MCP-1.

ribes missouriense/pretilost

Effect of Anthocyanins on Metabolic Profiles in Subjects With Pre-diabetes

Effect of Soft Fruit on Postprandial Blood Glucose

The Effects Grapes on Health Indices

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