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8 rezultatima
Alterations in potassium currents may trigger neurodegeneration in murine scrapie.
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Prijava Registriraj se
Conventional electrophysiological intracellular recording techniques were used to test the hypothesis that enhanced calcium entry via voltage-gated calcium channels or the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor-channel complex may be a primary pathological mechanism triggering
Sodium and potassium in scrapie brain.
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Potassium and Hemoglobin Types in Sheep with Special Reference to the Transmission of Scrapie.
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Effect of chemicals, heat, and histopathologic processing on high-infectivity hamster-adapted scrapie virus.
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High-titered (greater than 10(10) LD50 [50% lethal dose[/g) preparations of scrapie virus-infected hamster brain were subjected to inactivation by various chemicals, autoclaving, and histopathologic processing. Sodium hypochlorite, which reduced infectivity by approximately 4 log LD50/g of brain
Validation of the R-Biopharm AG RIDASCREEN® Histamine (Enzymatic) Kit.
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Background: RIDASCREEN® Histamine (enzymatic) is an enzymatic test kit for quantification of histamine in fresh fish, canned fish, fish meal, cheese, and wine. Methods: Fish products are extracted with boiling water, while cheese is extracted with water, and the extract is treated with
Proper calibration of ultrasonic power enabled the quantitative analysis of the ultrasonication-induced amyloid formation process.
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To elucidate the mechanisms of ultrasonication on the amyloid fibril formation, we quantitatively determined the ultrasonic power using both calorimetry and potassium iodide (KI) oxidation, and under the properly calibrated ultrasonic power, we investigated the ultasonication-induced amyloid
Fate of pathological prion (PrP(sc)92-138) in soil and water: prion-clay nanoparticle molecular dynamics.
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Prijava Registriraj se
Pathogenic prion protein scrapie (PrP(sc)) may contaminate soils for decades and remain in water in colloidal suspension, providing infection pathways for animals through the inhalation of ingested dust and soil particles, and drinking water. We used molecular dynamics simulations to understand the
Degradation and destabilization of abnormal prion protein using alkaline detergents and proteases.
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Prijava Registriraj se
There is a limited number of reports regarding detergents and proteases inactivating, degrading, or destabilizing abnormal prion protein (PrPSc). In the present study, the effect of alkaline detergents and proteases on the breakdown of PrPSc in the absence of proteinase K (PK) (degradation) and the
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