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solamargine/leukemija
Veza se sprema u međuspremnik
4 rezultatima
Solamargine, a steroidal alkaloid glycoside, induces oncosis in human K562 leukemia and squamous cell carcinoma KB cells.
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OBJECTIVE
The aim of this study was to demonstrate that solamargine (SM) mediates its cytotoxicity via oncosis.
METHODS
The cytotoxicity of SM on cancer cells was examined by 3-(4,5-dimethylthiazol)-2 and 5-diphenyltetrazolium bromide assay. Cell membrane integrity was assessed by detecting the
A lysosomal-mitochondrial death pathway is induced by solamargine in human K562 leukemia cells.
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Prijava Registriraj se
Solamargine (SM), a steroidal alkaloid glycoside from Solanum nigrum L., displayed a superior cytotoxicity to many human tumor cells. Further investigation with human K562 leukemia cells found that SM could induce an early lysosomal rupture within 2h as assessed by acridine-orange relocation and
A new steroidal glycoside from the fruits of Solanum myriacanthum
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Prijava Registriraj se
A new cholestane-type steroidal glycoside, solamyriaside A (1), was isolated from the fruits of Solanum myriacanthum Dunal (Solanaceae), along with two known steroidal glycosides, namely, solaviaside A (2) and aculeatiside A (3), and three known steroidal alkaloid
Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes.
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Inhibition of cancer can occur via apoptosis, a genetically directed process of cell self-destruction that involves numerous biomarkers and signaling pathways. Glycoalkaloids are nitrogen-containing secondary plant metabolites found in numerous Solanaceous plants including eggplants, potatoes, and
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