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substance dependence/edema

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The possibility that stress associated with morphine administration or withdrawal will influence the blood-brain barrier (BBB) dysfunction, brain edema formation and brain pathology was examined in a rat model. Repeated daily administration of morphine (10 mg/kg, i.p.) resulted in drug dependence in

Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications.

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The advance of functional genomics revealed the superfamily of G-protein coupled receptors (GPCRs). Hundreds of GPCRs have been cloned but many of them are orphan GPCRs with unidentified ligands. The first identified orphan GPCR is the opioid receptor like orphan receptor, ORL1. It was cloned in
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