substance dependence/nikotin

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Unplugged, a Drug Use Prevention Program: Adaptation and Evaluation of Effectiveness Among Students in Chile

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Substance use and drug related disorders are important public health problems. Alcohol and illicit drug use account for 5.4% of the total burden of disease and the peak has been found in early adulthood (between ages 20 and 30 years). Most of substance use disorders start during adolescence, and it

Evaluation of the Efficacy of the Individually Adjusted Therapy Scale (ATI) on the Addiction Severity

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Addiction is one of the most prevalent psychiatric disorders in general population. In the DSM-5, substance abuse and substance dependence have been combined into a single substance use disorder and gambling disorder is now reclassified in the new substance-related and addictive disorders category.

Efficacy of Centervention-ATOD: An Implementation Tool for Dissemination of Evidence-based Programs for Substance Abuse

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Alcohol, tobacco, and other drug (ATOD) use among adolescents is a major public health problem with devastating personal, familial, and societal costs. Substance use in youth is associated with increased accidental injuries (including overdoses), psychiatric comorbidities, suicidality, school

Theta-Burst Stimulation as a Treatment for Reducing Cocaine Use

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Objectives: Illicit drug use affects tens of millions of Americans and costs nearly $200 billion annually in health care costs and lost productivity. Cocaine dependence accounts for 25% of reported lifetime drug dependence though few successfully abstain with treatment. For efforts toward positive

Neural Substrates of Emotion: Impact of Cocaine Dependence

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Individuals will be screened for eligibility over the telephone by a trained research assistant during which major inclusion/exclusion criteria will be assessed. Individuals who appear eligible will be invited for an in-person interview with a member of the research team. Prior to any study

Whole Coffee Fruit Concentrate Pilot Study 1

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Participants (n=23; 20 completing with usable data) will come to UCLA for 1 in-person screening visit and 4 weekly study visits, culminating in a total of 5 study visits. Those who meet eligibility criteria will take part in a baseline test session (before randomization) to collect cognitive and

Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study

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Preventing Drug Use in Low Income Clinic Populations

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The Quit Using Drugs Intervention Trial (QUIT) will be the first randomized controlled trial in the U.S. that is powered to detect the effect of a primary care clinician delivered brief intervention protocol for reducing 'at risk' drug use and drug-related harm among low-income adult patients (ages

Brain Networks and Addiction Susceptibility

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Objective. Identification of genetic risk factors predisposing to nicotine abuse and dependence, and elucidation of their neurobiological mechanisms of action, is critical to individualized treatments and prevention of nicotine addiction. Nicotine exerts its effects on the brain through nicotinic

Naltrexone for Antipsychotic-Induced Weight Gain

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Persons with severe mental illness (SMI) die, on average, 25 years earlier than the general population1. Most of this early mortality can be attributed to cardiovascular disease (CVD) and diabetes mellitus (DM), which are directly related to obesity. Obesity is a leading cause of preventable death

Exploring Occupancy of Dopamine D3 Receptor by Buspirone in Humans Using PET

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Buspirone is used for anxiety disorder treatment, a therapeutic effect that has been thought to be mediated through its partial agonist properties at the serotonin receptor. However, since one PET study in humans has shown low occupancy of the serotonin by buspirone in clinical doses and since the

4 mg Nicotine Polacrilex Gum and Swedish Portion Snus

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Fifteen healthy smokers are given single doses of General Onyx 1 g portion snus and General White 1g portion snus, respectively, and one piece of Nicorette 4 mg chewing gum. Serial blood samples are drawn before (0), 2, 4, 8, 16, 24, 30, 45, 60 minutes, 1.5, 2, 4, 6 and 8 hours after administration

Deep Low-Frequency Repetitive Transcranial Magnetic Stimulation for Cessation of Pathological Gambling

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Deep Low-Frequency Repetitive Transcranial Magnetic Stimulation for cessation of pathological gambling Introduction: Pathological gambling (PG) is characterized by a persistent pattern of continued gambling behavior despite its adverse consequences. PG is a chronic, progressive, male-dominated

Efficacy of Varenicline for Smokeless Tobacco Use in India

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The prevalence of smokeless tobacco use in the United States is low vs. cigarette smoking, yet rates have remained constant over the past few years. In contrast, the rate of smokeless tobacco use in India is 20%. Smokeless tobacco is a carcinogenic and responsible for ~10,000 deaths/year from oral

Automatic Versus Evaluative Components of Cue Reactivity

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Relapse to drug abuse often happens in the presence of stimuli that are associated with previous drug-use, and drug-taking behavior appears to be partly controlled by such cues. While some theories postulate that such facilitation is mediated by cue-induced craving states, others hypothesize that

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