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Action of melatonin on squamous cell carcinoma and other tumors of the oral cavity (Review).

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Melatonin (MLT; N-acetyl-5-metoxy-tryptamine) is a hormone that is principally synthesized in the pineal gland. MLT has been shown to exhibit a variety of functions. The hormone, which is a free radical scavenger, plays an immunomodulatory role, stimulates the proliferation and synthesis of type I

Exploitation of the unusual thermodynamic properties of human myeloperoxidase in inhibitor design.

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Myeloperoxidase plays a fundamental role in oxidant production by neutrophils. It uses hydrogen peroxide and chloride to catalyze the production of hypochlorous acid (HOCl), which contributes to both bacterial killing and oxidative injury of host tissue. Thus, MPO is an interesting target for

Selective EPR Detection of Primary Amines in Water with a Calix[6]azacryptand-Based Copper(II) Funnel Complex.

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A water-soluble calix[6]arene-based azacryptand was synthesized. The corresponding tren [tris(2-aminoethyl)amine] cap grafted at the small rim coordinates strongly a copper(II) ion over a wide range of pH. The host-guest properties of the complex were explored by EPR spectroscopy. Due to second

Study on the Binding Interaction of the α,α',δ,δ'-Tetramethylcucurbit[6]uril With Biogenic Amines in Solution and the Solid State.

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1H NMR spectroscopy and MALDI-TOF mass spectrometry were utilized to examine the binding interaction of α,α',δ,δ'-tetramethylcucurbit[6]uril (TMeQ[6]) and six biogenic amines (spermine, spermidine, 2-phenethylamine, tyramine, histamine, and tryptamine). Their 1H NMR spectra both at pD = 7 and pD = 3

[The significance of fiber for swine nutrition with special reference to HCl-treated straw meal].

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The term crude fibre according to the Weend analysis method is insufficient for the nutrition of pigs as it does not comprise pentosanes. During the cooking process they are hydrolysed with diluted acid and do not remain in the crude fibre fraction. As stomach HCl can also hydrolyse pentosane

Allosterically driven self-assemblies of interlocked calix[6]arene receptors.

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The construction of self-assembled receptors based on flexible concave subunits is a challenging task and constitutes an interesting approach to mimic binding processes occurring in biological systems. The receptors studied herein are based on flexible calix[6]arene skeletons bearing three (or more)

Structure and ligand-binding properties of the biogenic amine-binding protein from the saliva of a blood-feeding insect vector of Trypanosoma cruzi.

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Proteins that bind small-molecule mediators of inflammation and hemostasis are essential for blood-feeding by arthropod vectors of infectious disease. In ticks and triatomine insects, the lipocalin protein family is greatly expanded and members have been shown to bind biogenic amines, eicosanoids

Simultaneous exposure to nicotine and hyperoxia causes tumors in hamsters.

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BACKGROUND We have shown that the nicotine-derived nitrosamine 4-(methyl-nitrosamino)-3-(pyridyl)-1-butanone (NNK) causes a high incidence of neuroendocrine lung tumors in male Syrian golden hamsters when administered to animals maintained in an atmosphere of 60% hyperoxia. In vitro studies with

Comparative 3D QSAR study on β(1)-, β(2)-, and β(3)-adrenoceptor agonists.

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A quantitative structure-activity relationship study of tryptamine-based derivatives of β(1)-, β(2)-, and β(3)-adrenoceptor agonists was conducted using comparative molecular field analysis (CoMFA). Correlation coefficients (cross-validated r(2)) of 0.578, 0.595, and 0.558 were obtained for the

Catecholaminergic and serotoninergic brain structures in European green frogs: an autoradiographical study.

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Aminergic brain structures have been investigated by means of light microscopical autoradiography after injection of the tritiated catecholamines noradrenaline and dopamine and the indoleamine (or tryptamine) serotonin into the brain cavity of frogs of the Rana esculenta complex. These amines are

Anti-inflammatory properties of griseofulvin.

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Anti-inflammatory activity of griseofulvin has been investigated in comparison with indomethacin and flufenamic acid. In vitro, griseofulvin has been proved the most effective of these agents in suppressing the contractions of smooth muscle preparations induced by a variety of proposed mediators of

Revised Pharmacophore Model for 5-HT2A Receptor Antagonists Derived from the Atypical Antipsychotic Agent Risperidone.

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Pharmacophore models for 5-HT_2A receptor antagonists consist of two aromatic/hydrophobic regions at a given distance from a basic amine. We have previously shown that both aromatic/hydrophobic moieties are unnecessary for binding or antagonist action. Here, we deconstructed the

Therapeutic potential of melatonin in oral medicine and periodontology.

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Melatonin (N-acetyl-5-methoxy tryptamine) is a substance secreted by multiple organs in vertebrates. In addition to playing a part in the circadian cycle of the body, melatonin is known to have antioxidant, antiinflammatory, and antioncotic effects on human tissues. Oral cavity is affected by a

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