Derris Scandens Benth Extract VS Naproxen in Knee OA
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EstatiKonplete
Patwone
Mahidol University
Kolaboratè
Ministry of Health, Thailand
ESÈ KLINIK: NCT00503828
BioSeek: nct00503828
Mo kle
Abstrè
Derris Scandens Benth (family : Leguminosae) is a woody vine growing throughout Southeast Asia, including Thailand. The stem of D.Scandens has been widely use in Thai traditional medicine, foe example of myalgia. Previous study shown that D.Scandens Benth extract has the anti-inflammatory activity. Although NSAIDs are efficaciously in the treatment of osteoarthritis,but the GI side effect is still concerned. In this study we aim to investigate the efficacy and safety of D. Scandens Benth extract compared with Naproxen for therapy of patients with knee osteoarthritis.
Dat
| Dènye verifye: | 05/31/2009 |
| Premye Soumèt: | 07/17/2007 |
| Enskripsyon Estimasyon Soumèt: | 07/17/2007 |
| Premye afiche: | 07/18/2007 |
| Dènye Mizajou Soumèt: | 01/10/2010 |
| Dènye Mizajou afiche: | 01/12/2010 |
| Dat aktyèl kòmanse etid la: | 06/30/2007 |
| Dat Estimasyon Prensipal Estimasyon an: | 02/28/2009 |
| Dat estime fini etid la: | 02/28/2009 |
Kondisyon oswa maladi
Knee Osteoarthritis
Entèvansyon / tretman
Drug: Derris Scandens Benth
Drug: naproxen
Faz
Faz 3
Gwoup bra
| Bra | Entèvansyon / tretman |
|---|---|
| Active Comparator: naproxen Naproxen 500 mg/day for 4 weeks | Drug: naproxen Naproxen 500 mg/day for 4 weeks |
| Experimental: Derris Scandens Benth Derris Scandens Benth | Drug: Derris Scandens Benth Derris scandens Benth extracts (oral) 400 mg twice per day for 4 weeks |
Kritè kalifikasyon yo
| Laj ki kalifye pou etid | 50 Years Pou 50 Years |
| Sèks ki kalifye pou etid | All |
| Aksepte Volontè Healthy | Wi |
| Kritè | Inclusion Criteria: - Age >=50 yr - Known case of primary knee osteoarthritis - WOMAC pain subscale (item1) >= 5 - signed informed consent Exclusion Criteria: - hypersensitive to NSAIDs - history of peptic ulcer or melena - unable to walk , i.e. patient with severe spinal stenosis, myocardial infarction - history of intra-articular injection of knee within 3 months - status post knee replacement |
Rezilta
Mezi Rezilta Prensipal yo
1. WOMAC score [2, 4 weeks]
Mezi Rezilta Segondè
1. 6-minute walk, Quality of Life, adverse event [2, 4 weeks]
