Does Thiamine Help Vomiting and Nausea in Pregnancy?

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

Lyen an sove nan clipboard la

EstatiSispann

Patwone

HaEmek Medical Center, Israel

ESÈ KLINIK: NCT00861523

BioSeek: nct00861523

Mo kle

gerstmann-straussler-scheinker disease

Abstrè

There are different treatments for nausea and vomiting in pregnancy. According to the ACOG recommendations, promethazine is the first line of parenteral treatment after oral treatment had failed. Thiamine is given to prevent wernicke encephalopathy. This research try to find out whether thiamine helps the vomiting and nausea as well, by comparing the response to thiamine and promethazine in women who suffer from nausea and vomiting in pregnancy.

Deskripsyon

- Research groups: pregnant women eho visit the emergency room for nausea and vomiting in pregnancy, pregnancy age 12 weeks or less

- After basic examinations and hydration, the women will randomized to thiamine or promethazine treatment.

- If no improvement is shown, the patient will be treated with the other drug

- The patients will be interviewed on their current visit and every two weeks until 14th week of gestation

- The interview includes medical history and details about their illness, other treatments, hospitalization etc.

Dat

Dènye verifye:	05/31/2015
Premye Soumèt:	02/17/2009
Enskripsyon Estimasyon Soumèt:	03/11/2009
Premye afiche:	03/12/2009
Dènye Mizajou Soumèt:	06/20/2015
Dènye Mizajou afiche:	06/22/2015
Dat aktyèl kòmanse etid la:	01/31/2009
Dat Estimasyon Prensipal Estimasyon an:	12/31/2011
Dat estime fini etid la:	12/31/2011

Kondisyon oswa maladi

Hyperemesis Gravidarum

Entèvansyon / tretman

Drug: thiamine & promethazine

Faz

Faz 3

Gwoup bra

Bra	Entèvansyon / tretman
Active Comparator: 1. thiamine Pregnant women until 12 week of gestation who refer to the ER because of nausea and vomiting and didn't improve after hydration, will receive thiamine IV
Active Comparator: 2. promethazine Pregnant women until 12 week of gestation who refer to the ER because of nausea and vomiting and didn't improve after hydration, will receive promethazine IV

Kritè kalifikasyon yo

Laj ki kalifye pou etid	18 Years Pou 18 Years
Sèks ki kalifye pou etid	Female
Aksepte Volontè Healthy	Wi
Kritè	Inclusion Criteria: - Pregnant women until 12th week of gestation - The women visit the ER because of nausea and vomiting - The women didn't received thiamine yet Exclusion Criteria: - Pregnant women over 12th week of gestation - Women that received thiamine before - women that allergic to the studied drugs

Rezilta

Mezi Rezilta Prensipal yo

1. the improvement in nausea and/or vomiting after treatment [2 months after first visit in ER (until 14 week of pregnancy)]

Does Thiamine Help Vomiting and Nausea in Pregnancy?

Mo kle

thiamine

gerstmann-straussler-scheinker disease

nausea

vomiting

wernicke encephalopathy