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Entral Feeding in Acute Severe Pancreatitis

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Patwone
King Abdul Aziz Specialist Hospital

Mo kle

Abstrè

• A total of 60 patients admitted to King Abdulaziz Specialists Hospital between June 2018 and April 2020 with both a clinical and biochemical presentation of acute pancreatitis with the following inclusion criteria: Abdominal pain > 6 on the visual analogue scale without given analgesia , abdominal distension and tenderness with serum amylase and serum lipase at least 3 times the upper limit of the reference range (considering normal lipase level from 0-160 U/L, and normal amylase level from 0-100 U/L) with confirmed abdominal computerized axial tomography of grade D and E on Ranson and colleagues criteria(28) of inflamed pancreatic picture.

Deskripsyon

- The study was conducted on monitoring of four pillar for 13 days (data collected one day before feeding and every three days for 12 days). the first pillar comparing the effect of the two enteral feeding methods on the clinical condition of the acute severe pancreatitis and this monitored clinically and laboratory by fixed parameters, clinically, by abdominal pain which assessed by visual analogue scale (VAS). and laboratory, by both markers of severity of pancreatic acini destruction which assessed by serum amylase, lipase and Markers of severity of interstitial pancreatic tissue destruction which assessed by the level of Lactate Dehydrogenase level (LDH), Aspartate aminotransferase (AST), C-reactive protein, prostacyclin and interleukin 8. The second pillar include effect of the two enteral feeding methods on the patient's tolerance and these monitored in our study by both post-feeding vomiting and post feeding attacks of osmotic diarrhea and also abdominal pain. Third pillar include effect of the two enteral feeding methods on the patient's general condition and these monitored by follows the APACHE II Score, hemodynamics of the patients in both groups (Mean arterial blood pressure and pulse) and arterial oxygen saturation (Spo2). Fourth pillar include effect of the two enteral feeding methods on achieving satisfactory nutrition parameters of the patients and both albumin level, radium blood sugar and electrolytes (sodium and potassium level) used as indicator for this.

- All parameters observed one day before starting feeding and every 3 days for 12 days (duration of the study).

Dat

Dènye verifye: 04/30/2020
Premye Soumèt: 05/20/2020
Enskripsyon Estimasyon Soumèt: 05/26/2020
Premye afiche: 05/27/2020
Dènye Mizajou Soumèt: 05/26/2020
Dènye Mizajou afiche: 05/27/2020
Dat aktyèl kòmanse etid la: 06/09/2018
Dat Estimasyon Prensipal Estimasyon an: 04/01/2020
Dat estime fini etid la: 04/09/2020

Kondisyon oswa maladi

Postoperative Nausea

Entèvansyon / tretman

Device: Group A

Device: Group B

Drug: (erythromycin 250 mg IV bolus)

Faz

-

Gwoup bra

BraEntèvansyon / tretman
Group A
Group A received nasogastric feeding (NG), insure through ngt pump
Device: Group A
• The insertion of NG tubes were performed by the ICU physician and the position was checked by auscultation of gas from 50 ml syringe by injecting 20 ml of air in the NG and by X-ray abdomen to be sure from the site of NG tube
Group B
receive feeding throughThe nasojejunal tube is silicone or polyurethane tube with an inner stylet that is positioned (under fluoroscopic guidance) beyond the ligament of Treitz. Patients were placed in right lateral position
Device: Group B
The nasojejunal tube is silicone or polyurethane tube with an inner stylet that is positioned (under fluoroscopic guidance) beyond the ligament of Treitz. Patients were placed in right lateral position

Kritè kalifikasyon yo

Laj ki kalifye pou etid 18 Years Pou 18 Years
Sèks ki kalifye pou etidAll
Metòd echantiyonajProbability Sample
Aksepte Volontè HealthyNon
Kritè

Inclusion Criteria:

- acute pancreatitis

Exclusion Criteria:

- systemic disease as hypertension or diabetes

Rezilta

Mezi Rezilta Prensipal yo

1. effect of different methods of feeding in the clinical condition of the acute severe pancreatitis [13 days]

first pillar comparing the effect of the two enteral feeding methods on the clinical condition of the acute severe pancreatitis,The second pillar include effect of the two enteral feeding methods on the patient's tolerance

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