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Phytochemistry 2008-Nov

Diversolides A-G, guaianolides from the roots of Ferula diversivittata.

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Mehrdad Iranshahi
Seyyed Tahmineh Hosseini
Ahmad Reza Shahverdi
Kamyar Molazade
Saleha Suleman Khan
Viqar Uddin Ahmad

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Abstrè

Seven sesquiterpene lactone derivatives, diversolides A-G (1-7), together with two known compounds, diversin (8) and stigmasterol, were isolated from the roots of Ferula diversivittata. The structures of these compounds were elucidated by extensive spectroscopic methods including 1D-(1H and 13C) and 2D-NMR experiments (DQF-COSY, HSQC, HMBC, and NOESY) as well as high-resolution EIMS. Compounds 1, 4 and 6-8 were tested for their in vitro antifungal and antibacterial activities. Some of the tested compounds showed moderate antifungal and antibacterial activities with minimum inhibitory concentration (MIC) values from 40 to 80microg/ml.

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