Yao xue xue bao = Acta pharmaceutica Sinica 2004-Mar
[Synthesis and anti-inflammatory analgesic activities of sinomenine derivatives].
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Abstrè
OBJECTIVE
To provide basic data for the synthesis of new sinomenine derivatives.
METHODS
The C ring in sinomenine was modified.
RESULTS
Seven compounds were prepared and screened for anti-inflammatory and analgesic activities. Compounds 2 and 5 showed better activities.
CONCLUSIONS
Modification of the C ring in sinomenine should be worthy to be studied further.
