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agranulocytosis/obesity

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Mast cell activation syndrome masquerading as agranulocytosis.

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Acquired agranulocytosis is a rare, life-threatening disorder. The few known causes/associations usually are readily identifiable (e.g., drug reaction, Felty syndrome, megaloblastosis, large granular lymphocytic leukemia, etc.). We report a novel association with mast cell disease. A 61-year-old
BACKGROUND Bariatric surgery is a valuable therapeutic option to severe obesity. Many researches have assessed the procedure efficiency on weight reduction, improvement in comorbidities and reduction of mortality. However, studies of late mortality and its causes are still necessary, mainly in the

Sudden death in schizophrenia.

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OBJECTIVE To examine the recent literature regarding sudden death in patients with schizophrenia and synthesize salient conclusions based on this evidence. RESULTS Sudden cardiac death (SCD) is the largest subset of sudden unexpected death (SUD), with up to 40% of SUD from cardiovascular causes. SCD

Management of clozapine treatment during the COVID-19 pandemic

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Clozapine is the only available treatment for refractory schizophrenia but its use involves frequent physical contact with healthcare workers for the purpose of mandatory blood monitoring. During the COVID-19 pandemic, patients taking clozapine will be self-isolating to reduce the risk of infection,

The measurement of health-related quality of life (QOL) in paediatric clinical trials: a systematic review.

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BACKGROUND The goal of much care in chronic childhood illness is to improve quality of life (QOL). However, surveys suggest QOL measures are not routinely included. In addition, there is little consensus about the quality of many QOL measures. OBJECTIVE To determine the extent to which quality of
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