agranulocytosis/triglyceride

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Clozapine-Induced Cardiotoxicity Presenting as Sepsis: A Case Report and Literature Review.

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Clozapine is an atypical antipsychotic agent indicated in the treatment of medication-resistant schizophrenia. It is often reserved as a last line of treatment owing to the potential for serious and potentially life-threatening side effects, the most serious being agranulocytosis requiring close

Overview of acne and its treatment.

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Acne affects more than 85% of teenagers in the United States and often continues into adulthood. The most deleterious form can result in permanent scarring on the face, chest, and back. Although the pathogenic features of acne are well known, the initiating factor remains unknown. Isotretinoin is

Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3).

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The phospholipid scramblases (PLSCR1 to PLSCR4) are a structurally and functionally unique class of proteins, which are products of a tetrad of genes conserved from Caenorhabditis elegans to humans. The best characterized member of this family, PLSCR1, is implicated in the remodeling of the

Phase II trial of isotretinoin and recombinant interferon alfa-2a in metastatic colorectal carcinoma.

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Phase II trials of the novel biologic combination isotretinoin (13-cis-retinoic aid) plus recombinant interferon alfa-2a have demonstrated this combination's major activity against advanced squamous cell carcinoma of the skin and cervix. Because this combination has had limited study in other

A phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients.

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We report a phase I clinical investigation of 30-minute and four-hour intravenous (IV) infusions of recombinant tumor necrosis factor (rTNF)-alpha. Thirty-nine patients with disseminated cancer received escalating doses of rTNF-alpha for five consecutive days every 2 weeks for a total duration of 8

Hematological and cardiometabolic safety of clozapine in the treatment of very early onset schizophrenia: a retrospective chart review.

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OBJECTIVE There are very few studies in the literature regarding clozapine use in children <13 years of age. In this retrospective chart review, we compared the safety of clozapine--as determined by hematological and cardiometabolic changes - to that of non-clozapine antipsychotics used in the

Clozapine versus other atypical antipsychotics for schizophrenia.

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BACKGROUND Clozapine is an atypical antipsychotic demonstrated to be superior in the treatment of refractory schizophrenia which causes fewer movement disorders. Clozapine, however, entails a significant risk of serious blood disorders such as agranulocytosis which could be potentially fatal.

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