anophthalmos/veratrum

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Cyclopamine and related steroidal alkaloid teratogens: their occurrence, structural relationship, and biologic effects.

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A spontaneous congenital deformity is produced in lambs whose dams consume Veratrum californicum on the 14th day of gestation. The deformity is generally expressed as cyclopia, cebocephaly, anophthalmia, or microphthalmia. This teratogenic effect is produced by certain steroidal alkaloid teratogens

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Herbal & Natural Medicine

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