arachidonate/sarcoma

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Alterations in lipid acyl group composition and membrane structure in cells transformed by Rous sarcoma virus.

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The acyl group composition of the phospholipids from normal chick embryo fibroblasts and from cells transformed by Rous sarcoma virus was determined by gas-liquid chromatography. Rous-transformed cells had less arachidonate (20:4) and more oleate (18:1) in membrane lipids than normal, growing cells.

Arachidonate metabolism increases as rat alveolar type II cells differentiate in vitro.

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Rat type II alveolar epithelial cells are known to undergo morphological and functional changes when maintained in culture for several days. Having previously demonstrated that these cells can deacylate free arachidonic acid (AA) and metabolize it to products of the cyclooxygenase pathway, the

Modulation of arachidonic acid metabolism by Rous sarcoma virus.

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Arachidonic acid (C20:4) metabolites were released constitutively from wild-type Rous sarcoma virus-transformed chicken embryo fibroblasts (CEF). 3H-labeled C20:4 and its metabolites were released from unstimulated and uninfected CEF only in response to stimuli such as serum, phorbol ester, or the

The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.

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Fatty acid uptake and metabolism are often dysregulated in cancer cells. Fatty acid activation is a critical step that allows these biomolecules to enter cellular metabolic pathways such as mitochondrial β-oxidation for ATP generation or the lipogenic routes that generate bioactive lipids such as

Restriction of patching of bound concanavalin A after incorporation of arachidonic acid into the plasma membrane of virally transformed fibroblasts.

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Topographical distribution of concanavalin A binding sites (CABS) was studied in two lines of virally transformed fibroblasts as a function of fatty acid composition. Fatty acid composition was manipulated by incubating cells in fatty acid, ATP, CoA, and delipidated fetal calf serum (FCS). VLM cells

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