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Some of the elk (Cervus elaphus nelsoni) of the Greater Yellowstone Area (Wyoming, Idaho, Montana; USA) are infected with Brucella abortus, the bacterium that causes bovine brucellosis. Brucella abortus strain RB51 vaccine is being considered as a means to control B. abortus induced abortions in cow
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OBJECTIVE
To develop a novel oral vaccine delivery system for swine, using the rough vaccine strain of Brucella abortus.
METHODS
56 crossbred pigs from a brucellosis-free facility.
METHODS
In 3 separate experiments, pigs were orally vaccinated with doses of 1 x 10(9) to > 1 x 10(11) CFU of strain
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