capsella/necrosis

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First Report of Downy Mildew of Spider Flower Caused by a Hyaloperonospora sp. in Korea.

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Spider flower, Tarenaya hassleriana (Chodat) H. H. Iltis (synonym Cleome hassleriana; C. spinosa), which is native to South America, is now cultivated as an ornamental plant worldwide. In Korea, this plant has recently become popular in gardens and parks because of its beautiful flowers. During July

First Report of White Blister Rust Caused by Albugo candida on Wasabi in Korea.

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Wasabi (Wasabia japonica (Miq.) Matsum.), a member of the Brassicaceae family, is a commercially important crop in East Asian countries such as China, Japan, Korea, and Taiwan. In Korea, wasabi is under commercial development since it has become popular as a condiment due to its strong pungent

Activation of phosphoinositide 3-kinase, protein kinase C, and extracellular signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cells.

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Our previous study showed that oridonin isolated from Rabdosia rubescens enhanced phagocytosis of apoptotic cells by macrophage-like U937 cells through tumor necrosis factor (TNF) alpha and interleukin (IL)-1beta release. In this study, we further investigated signaling events involved in

Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways.

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This study found that oridonin, a natural diterpenoid purified from Rabdosia rubescens, inhibited growth of multiple myeloma (MM; U266, RPMI8226), acute lymphoblastic T-cell leukemia (Jurkat), and adult T-cell leukemia (MT-1) cells with an effective dose that inhibited 50% of target cells (ED50)

Antiproliferation effects of oridonin on HPB-ALL cells and its mechanisms of action.

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Oridonin, an ent-kaurane diterpenoid derived from the herbal Rabdosia rubescens, has been recently reported to have antitumor effects on a large variety of cancer cells. The present study was undertaken to investigate the in vitro antiproliferation and apoptosis inducing effects of oridonin on

Oridonin stabilizes retinoic acid receptor alpha through ROS-activated NF-κB signaling.

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BACKGROUND Retinoic acid receptor alpha (RARα) plays an essential role in the regulation of many biological processes, such as hematopoietic cell differentiation, while abnormal RARα function contributes to the pathogenesis of certain diseases including cancers, especially acute promyelocytic

Oridonin enhances TRAIL-induced apoptosis through GALNT14-mediated DR5 glycosylation.

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Oridonin is a diterpenoid isolated from the Rabdosia rubescens and has multiple biological effects, such as anti-inflammation and anti-tumor activities. In present study, we revealed that the sensitizing effect of oridonin on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced

Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38-MAPK and TLR4/NF-κB signaling pathways.

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Inflammation plays a pivotal role in the development and progression of diabetic nephropathy (DN). Oridonin (Ori), a component isolated from Rabdosia rubescens, possesses remarkable anti-inflammatory, immunoregulatory and antitumor properties. However, the renoprotective effects of Ori and the

Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia.

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Microglial activation has been implicated in many neurological disorders for its inflammatory and/or neurotrophic effects. In this study, we investigated the effects upon activated microglia of Oridonin (Ori), an effective component isolated from Rabdosia rubescens. We pretreated rat primary

Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation, dependent on the cytochrome c/caspase-9 apoptosome.

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Two diterpenoids, oridonin (1) and ponicidin (2), were isolated from the 95% ethanol extract of Rabdosia rubescens and were evaluated for antiproliferative activity on cancer cells and human peripheral blood mononuclear cells (PBMC) in vitro. Oridonin has much more potent cytotoxic effects on four

Survival of Young Immature Capsella Embryos Cultured in vitro.

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The survival rate of immature Capsella embryos cultured in vitro varies according to their length and the mineral solution used. Some elements are toxic while others increase survival. Nevertheless, in spite of an improvement in the composition of the nutritive solution, globular embryos of less

First Report of Tatsoi Downy Mildew Caused by Hyaloperonospora brassicae in Korea.

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Tatsoi (Brassica narinosa L.H. Bailey), also called spinach mustard or spoon mustard, is cultivated for edible greens in Asia. In Korea, this plant has recently become popular as a sprout vegetable that is grown to harvestable size in 5 to 6 days. During April 2012, tatsoi seedlings showing typical

Natural limonoids protect mice from alcohol-induced liver injury.

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Background Alcoholic liver disease (ALD) is regarded as a global health problem with limited therapeutic options. Previous studies highlighted some anticancer, antiviral, and hepatoprotective activities of limonoids, but the effects of these compounds on ALD remain unknown. The present study aimed

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