cardenolide/digitalis

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An overview of cardenolides in Digitalis - more than a cardiotonic compound.

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The genus Digitalis L. containing species, commonly known as the "foxglove", is the main source of cardenolides, which have various pharmacological properties effective against certain pathological conditions including myocardial infarction, arterial hypertension, cardiac dysfunction, angina, and

Profiling and structural analysis of cardenolides in two species of Digitalis using liquid chromatography coupled with high-resolution mass spectrometry.

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Plants of the Digitalis genus contain a cocktail of cardenolides commonly prescribed to treat heart failure. Cardenolides in Digitalis extracts have been conventionally quantified by high-performance liquid chromatography yet the lack of structural information compounded with possible co-eluents

Defense of Milkweed Bugs (Heteroptera: Lygaeinae) against Predatory Lacewing Larvae Depends on Structural Differences of Sequestered Cardenolides

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Predators and parasitoids regulate insect populations and select defense mechanisms such as the sequestration of plant toxins. Sequestration is common among herbivorous insects, yet how the structural variation of plant toxins affects defenses against predators remains largely unknown. The

Expression of recombinant Digitalis lanata EHRH. cardenolide 16'-O-glucohydrolase in Cucumis sativus L. hairy roots.

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The coding sequence for the Digitalis lanata EHRH. cardenolide 16'-O-glucohydrolase was inserted downstream of the 35S promoter in the binary vector pBI121 resulting in plant expression vector pBI121cgh. Cotyledon explants excised from 10-day-old seedlings of Cucumis sativus L. were transformed

Isolation of cardenolides from a Brazilian cultivar of Digitalis lanata by rotation locular counter-current chromatography.

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Cardenolides from a Brazilian cultivar of Digitalis lanata were isolated by rotation locular countercurrent chromatography (RLCC), employing dichloromethane-methanol-water (5:6:4, v/v) as the solvent system. Highly pure lanatoside C was obtained from the Digitalis lanata hydromethanolic extract,

Enhancement of cardenolide and phytosterol levels by expression of an N-terminally truncated 3-hydroxy-3-methylglutaryl CoA reductase in Transgenic digitalis minor.

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Pathway engineering in medicinal plants attains a special significance in Digitalis species, the main industrial source of cardiac glycosides, steroidal metabolites derived from mevalonic acid via the triterpenoid pathway. In this work, the Arabidopsis thaliana HMG1 cDNA, coding the catalytic domain

Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae.

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A yeast expression plasmid was constructed containing a cardenolide biosynthetic module, referred to as CARD II, using the AssemblX toolkit, which enables the assembly of large DNA constructs. The genes cloned into the vector were (a) a Δ⁵ -3β-hydroxysteroid dehydrogenase gene from

Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture.

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Recent studies demonstrate that cardiac glycosides, known to inhibit Na+/K+-ATPase in humans, have increased susceptibility to cancer cells that can be used in tumor therapy. One of the most promising candidates identified so far is glucoevatromonoside, which can be isolated from the endangered

[Incidence and biosynthesis of cardenolides in tissue cultures of Digitalis purpurea and Digitalis lanata. 1. Cardenolides in surface-cultures of cotyledones and leaves of Digitalis purpurea].

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[Observations on the occurrence and the formation of cardenolides in tissue cultures of Digitalis purpurea and Digitalis lanata. 2. Cardenolides in submerse cultures of the leaves of Digitalis purpurea (author's transl)].

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[Stability and technology of ampule solutions of cardenolides of the wooly foxglove (Digitalis lanata Ehrh.)].

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[Cardenolides in callus cultures of Digitalis purpurea and Digitalis lanata. III. Callus cultures derived from roots (author's transl)].

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[Biotransformation of cardenolides by cell suspension cultures of Digitalis lanata and Thevetia neriifolia (author's transl)].

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Acaricidal effects of cardiac glycosides, azadirachtin and neem oil against the camel tick, Hyalomma dromedarii (Acari: Ixodidae).

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The cardiac glycoside, digitoxin, from Digitalis purpurea L (Scrophulariaceae), a cardiac glycosidal (cardenolide) extract from Calotropis procera (Ait) R Br (Asclepiadaceae), azadirachtin and neem oil from Azadirachta indica A Juss (Meliaceae) were tested for their effects against larvae and adult

Summer pheasant's eye (Adonis aestivalis) poisoning in three horses.

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Three horses died as a result of eating grass hay containing summer pheasant's eye (Adonis aestivalis L.), a plant containing cardenolides similar to oleander and foxglove. A 9-year-old thoroughbred gelding, a 20-year-old appaloosa gelding, and a 5-year-old quarter horse gelding initially presented

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