cataract/hypoxia

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Acute reversible lens opacity: caused by drugs, cold, anoxia, asphyxia, stress, death and dehydration.

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[Investigations on lenticular opacity due to anoxia. I. a) Conditions of development of so-called anoxic cataract and its morphological aspects. b) Anaerobic glycolytic activity of the crystallin lens in anoxia. c) Influence of various conditions on the anoxic state of the lens].

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[Cataracts and anoxia in the premature infants].

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Effect of HSF4b on age related cataract may through its novel downstream target Hif1α.

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Our previous study identified five new heat shock factor 4 (HSF4) mutations in 150 age-related cataract (ARC) patients which indicated that HSF4 mutations may be associated with this disease. Hypoxia-inducible factor (Hif1α) is an important downstream target of HSF4b. It has been found that Hif1α

Oxygen application by a nasal probe prevents hypoxia but not rebreathing of carbon dioxide in patients undergoing eye surgery under local anaesthesia.

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OBJECTIVE Hypoxia and carbon dioxide rebreathing are potential problems during eye surgery in spontaneously breathing patients. The aim of the present study was to determine effectiveness of nasal application of oxygen to prevent hypoxia and carbon dioxide accumulation in spontaneously breathing

Notch1 signaling induces epithelial-mesenchymal transition in lens epithelium cells during hypoxia.

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BACKGROUND Posterior Capsular Opacification (PCO) is one of the most common complications of cataract surgery which can result in severe visual damage. Epithelial-Mesenchymal Transition (EMT) of lens epithelium cells (LEC) is the pathological basis of PCO. Recent research showed that hypoxia acted

Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells.

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Quercetin is a dietary bioflavonoid which has been shown to inhibit lens opacification in a number of models of cataract. The objectives of this study were to determine gene expression changes in human lens epithelial cells in response to quercetin and to investigate in detail the mechanisms

[Establishment of a neonatal rat model of periventricular leukomalacia and its concomitant cataract].

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OBJECTIVE To establish a reliable neonatal rat model of periventricular leukomalacia (PVL) which is expected to be similar to PVL of human preterm infants pathologically, and to explore the concomitant eye lesions in the PVL model. METHODS Two-old-day neonatal rats were randomly divided into a PVL

Effect of single-dose fentanyl on the cardiorespiratory system in elderly patients undergoing cataract surgery.

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OBJECTIVE To evaluate the effects of fentanyl on the cardiorespiratory system in elderly patients undergoing cataract surgery with phacoemulsification method. METHODS Randomized, prospective, double-blind study. METHODS University hospital. METHODS 70 ASA physical status I, II, and III patients (>60

Preoperative intravenous clonidine in the surgical treatment of cataract: evaluation of the clinical benefits.

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OBJECTIVE Clonidine has been used in anesthesia for its sedative and analgesic properties, and to achieve greater hemodynamic stability with reduction in intra-ocular pressure. This study evaluated the clinical effects of intravenous clonidine (2.5 microg.kg(-1)) on the intra-ocular pressure (IOP),

Protein kinase C epsilon activates lens mitochondrial cytochrome c oxidase subunit IV during hypoxia.

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Protein kinase C (PKC) isoforms have been identified as major cellular signaling proteins that act directly in response to oxidation conditions. In retina and lens two isoforms of PKC respond to changes in oxidative stress, PKCgamma and PKCepsilon, while only PKCepsilon is found in heart. In heart

Anterior-chamber hypoxia and iris vasculopathy in pseudoexfoliation syndrome.

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Iris vasculopathy is a well-recognized clinical feature in pseudoexfoliation syndrome (PES). In the present study we examined the morphology of the iris vasculature in PES using electron microscopy and we tested whether these iris vascular changes were correlated with an impaired oxygen supply to

Vitamin C decreases VEGF expression levels via hypoxia‑inducible factor‑1α dependent and independent pathways in lens epithelial cells.

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Posterior capsular opacification (PCO) is the main complication following cataract surgery. The proliferation of the residual lens epithelial cells (LECs) serves an important role in PCO formation. The authors' previous study revealed that vitamin C inhibited the proliferation of human LECs by

Age-dependent control of lens growth by hypoxia.

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OBJECTIVE The lens grows continuously throughout life, but the factors that influence the size of the adult lens are not known. Lens thickness is a significant risk factor for age-related cataract. It has been postulated that the hypoxic environment in the eye protects the lens from nuclear

Effects of cataract surgery on corneal function.

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Recent reports suggest that the aphakic eye develops less corneal edema than the phakic eye during hydrogel contact lens wear. Measurements were made of several ocular characteristics that might account for this difference in nine unilateral aphakic subjects. The measurements showed that compared

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