cervical intraepithelial neoplasia/nicotine

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Lifetime exposure to environmental tobacco smoke and cervical intraepithelial neoplasms among nonsmoking Taiwanese women.

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Cigarette smoke is one of the most important environmental risk factors for the development of cervical intraepithelial neoplasms (CINs). Given that the prevalence of cigarette smoking in Taiwanese women is very low, compared with Caucasian women (3-4% vs. approximately 28%, respectively), direct

Smoking and cervical intraepithelial neoplasia: nicotine and cotinine in serum and cervical mucus in smokers and nonsmokers.

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A blood sample before treatment was taken from 35 women with cervical intraepithelial neoplasia. Levels of nicotine and cotinine were analyzed by radioimmunoassay. Both cotinine and, especially, nicotine were shown to be strongly concentrated in cervical mucus compared with serum levels. These

Association of Combined Tobacco Smoking and Oral Contraceptive Use With Cervical Intraepithelial Neoplasia 2 or 3 in Korean Women.

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BACKGROUND Cigarette smoking and oral contraceptive (OC) use have been associated with cervical neoplasia, and the combination of smoking and OC use could influence cervical carcinogenesis. We aimed to assess the joint effect of smoking and OC use on the risk of cervical intraepithelial neoplasia

The cellular transcription factor Brn-3a and the smoking-related substance nicotine interact to regulate the activity of the HPV URR in the cervix.

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The cellular transcription factor Brn-3a differentially regulates different human papilloma virus (HPV)-16 variants that are associated with different risks of progression to cervical carcinoma in infected humans. The upstream regulatory regions (URRs) of high- and intermediate-risk HPV-16 variants

The Preventive Effect of Dietary Antioxidants Against Cervical Cancer Versus the Promotive Effect of Tobacco Smoking.

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Uterine cervical cancer is the fourth most common cancer in women, and its etiology has been recognized. High-risk human papilloma virus (HR-HPV) infection induces an opportunity for malignant transformation. This paper discusses the current issues based on a review of the literature and compares

Predictors of Follow-Up in Women with Cervical Intraepithelial Neoplasia 2-3.

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OBJECTIVE To describe a cohort of women receiving care after abnormal Pap smears and to assess predictors of follow-up in a cohort of women with cervical intraepithelial neoplasia (CIN) 2-3. METHODS This was a retrospective cohort study of women attending a colposcopy clinic in 2011. Data was

Prognostic scores after surgical treatment for cervical intraepithelial neoplasia: a proposed model and possible implications for post-operative follow-up.

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OBJECTIVE To develop a prognostic model for women who underwent surgical treatment for cervical intraepithelial neoplasia. METHODS Cohort study. Patient inclusion and follow-up occurred retrospectively and prospectively. METHODS Barretos Cancer Hospital, Barretos, São Paulo, Brazil. METHODS Women (n

Epidemiological characteristics related to treatment failure of preinvasive cervical intraepithelial neoplasia among Brazilian women.

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OBJECTIVE To evaluate cervical intraepithelial neoplasia (CIN) treatment failure among women with an altered Papanicolaou test and treated at a public cervical pathology center in Rio de Janeiro, Brazil. METHODS An exploratory study was carried out in a cohort of women treated for preinvasive

Associations of dietary dark-green and deep-yellow vegetables and fruits with cervical intraepithelial neoplasia: modification by smoking.

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Smoking has been positively and fruit and vegetable intake has been negatively associated with cervical cancer, the second most common cancer among women worldwide. However, a lower consumption of fruits and reduced serum carotenoids have been observed among smokers. It is not known whether the

Role of active and passive smoking in high-risk human papillomavirus infection and cervical intraepithelial neoplasia grade 2 or worse.

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OBJECTIVE We performed a pooled analysis to examine cigarette smoking and household passive smoke exposure in relation to the risk of human papillomavirus (HPV) infection and cervical intraepithelial neoplasia grade 2+ (CIN2+). METHODS Data were pooled from 12 cross-sectional studies for cervical

Chapter 3: Cofactors in human papillomavirus carcinogenesis--role of parity, oral contraceptives, and tobacco smoking.

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It is now well established that infection with oncogenic human papillomavirus (HPV) types is the necessary cause of cervical cancer (CC) and its immediate precursor cervical intraepithelial neoplasia 3. However, HPV infection alone may not be sufficient to cause CC, and other exogenous and

Factors associated with colposcopy-histopathology confirmed cervical intraepithelial neoplasia among HIV-infected women from Rio De Janeiro, Brazil.

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BACKGROUND Despite the availability of preventive strategies (screening tests and vaccines), cervical cancer continues to impose a significant health burden in low- and medium-resourced countries. HIV-infected women are at increased risk for infection with human papillomavirus (HPV) and thus

Basic Science, Epidemiology, and Screening for Anal Intraepithelial Neoplasia and Its Relationship to Anal Squamous Cell Cancer.

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Despite the progress made in the reduction of squamous cell carcinoma of the cervix, the incidence of anal squamous cell carcinoma (ASCC) has been increasing since 1992. While it remains an uncommon disease, the prevalence is climbing steadily. Among human immunodeficiency virus (HIV)-infected

The biology of incipient, pre-invasive or intraepithelial neoplasia.

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Invasive tumors (cancers or malignant lesions) typically develop in the setting in which there is the presence of putative non-invasive lesions and the development of these non-invasive lesions frequently precedes the development of cancers. For some organs, such as the oral cavity, cervix and skin,

The clinical importance of atypical glandular cells of undetermined significance on the cytologic smear.

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The objective of the study was to assess the prevalence of underlying cervical and endometrial lesions among patients with atypical glandular cells of undetermined significance (AGCUS) on the cytologic smear. Eighty-six patients with AGCUS, without evidence of squamous intraepithelial lesions,

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