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Coptisine protects cardiomyocyte against hypoxia/reoxygenation-induced damage via inhibition of autophagy.
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Coptisine is a natural occurring isoquinoline alkaloid isolated from the traditional Chinese medicinal herb Rhizoma coptidis. Coptisine has been reported to have protective effects on reperfusion injury in cardiomyocytes, however, the underlying mechanism remains uncertain. Here, we used a
Coptisine alleviates ischemia/reperfusion-induced myocardial damage by regulating apoptosis-related proteins
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Coptisine is an alkaloid with many biological functions, but studies on its mechanism in myocardial ischemia-reperfusion (I/R) injury are less reported. Hypoxia-reoxygenation (H/R) -treated cardiomyocytes injury and I/R-induced myocardial tissues damage were created in rat models with or without the
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