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corydalis decumbens/potasyòm
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Effects of allocryptopine on outward potassium current and slow delayed rectifier potassium current in rabbit myocardium.
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OBJECTIVE
Allocryptopine (ALL) is an effective alkaloid of Corydalis decumbens (Thunb.) Pers. Papaveraceae and has proved to be anti-arrhythmic. The purpose of our study is to investigate the effects of ALL on transmural repolarizing ionic ingredients of outward potassium current (I to) and slow
Allocryptopine and benzyltetrahydropalmatine block hERG potassium channels expressed in HEK293 cells.
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OBJECTIVE
Allocryptopine (ALL) is an alkaloid extracted from Corydalis decumbens (Thunb) Pers. Papaveraceae, whereas benzyltetrahydropalmatine (BTHP) is a derivative of tetrahydropalmatine extracted from Corydalis ambigua (Pall) Cham et Schlecht. The aim of this study was to investigate the effects
Simultaneous quantification of 11 isoquinoline alkaloids in Corydalis impatiens (Pall.) Fisch by HPLC.
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Isoquinoline alkaloids are the primary active ingredients of Corydalis, but an analytical method for quality assessment of the active ingredients in Corydalis impatiens (Pall). Fisch has not been reported. A new, simple, and multiple-component quantification method was developed for the simultaneous
[Preparation and simultaneous determination of corynoline and acetylcorynoline in the herb of Corydalis bungeana].
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OBJECTIVE
To isolate and purify corynoline and acetylcorynoline from Corydalis bungeana and develop a reversed-phase HPLC method of determining the two components in C. bungeana.
METHODS
Alkaloids were isolated from the ethanolic extract with column gel chromatography, and identified on the basis of
Ca(2+)-channel blockade in rat thoracic aorta by protopine isolated from Corydalis tubers.
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The pharmacological properties and mechanism of the action of protopine on isolated rat thoracic aorta were examined. It inhibited norepinephrine (NE, 3 microM)-induced tonic contraction in rat thoracic aorta in a concentration-dependent manner (25-100 micrograms/ml). The phasic contraction caused
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