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cremastra appendiculata/atrophy
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Homoisoflavanone inhibits retinal neovascularization through cell cycle arrest with decrease of cdc2 expression.
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Neovascularization in the eye is the most common cause of blindness in all age groups; retinopathy of prematurity (ROP), diabetic retinopathy, and age-related macular degeneration. Despite current advances in surgical treatments, ROP remains as the most serious problem of vision loss in children.
Synthesis and mechanistic studies of a novel homoisoflavanone inhibitor of endothelial cell growth.
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Preventing pathological ocular angiogenesis is key to treating retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration. At present there is no small molecule drug on the market to target this process and hence there is a pressing need for developing novel small
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