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dactylicapnos/protopine
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[Determination of protopine and isocorydine in root of Dactylicapnos scandens by HPLC].
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Log In / Enskri
OBJECTIVE
To establish a HPLC method for determination of protopine and isocorydine in root of Dactylicapnos scandens.
METHODS
The separation was performed in a PHENOMENEX-C18 column with a mobile phase of methanol-0.2% phosphoric acid (adjusted to pH 7.0 with triethylamine)(50:50), The detection
Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models.
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Log In / Enskri
The protopine isolated from a Chinese herb Dactylicapnos scandens Hutch was identified as an inhibitor of both serotonin transporter and noradrenaline transporter in vitro assays. 5-hydroxy-DL-tryptophan(5-HTP)-induced head twitch response (HTR) and tail suspension test were adopted to study whether
[Alkaloids from Dactylicapnos scandens Hutch].
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OBJECTIVE
To investigate the alkaloids in the roots of Dactylicapnos scanden (D. Don) Hutch.
METHODS
The compounds were isolated by various column chromatographic methods. The structures were elucidated by spectroscopic analysis.
RESULTS
Eight compounds were isolated and identified as d-isocorydine
Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of Dactylicapnos scandens in rats.
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The herbal ingredients of isocorydine and protopine were isolated from Dactylicapnos scandens. This study was aimed at developing a liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method to quantify isocorydine and protopine in rat plasma and tissues for
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