deguelin/derris

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Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention.

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Deguelin is a natural compound of the flavonoid family products isolated from Derris trifoliata Lour. or Mundulea sericea (Leguminosae). It exhibited significant anti-tumorigenesis and anti-proliferative activity in various types of cancer both in vitro and in vivo. Deguelin induced cell apoptosis

A high content (minus)-deguelin concentrate from a commercial derris resin by steady-state distribution.

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7a-O-methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoliata.

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From the acetone extract of the roots of Derris trifoliata an isoflavonoid derivative, named 7a-O-methyldeguelol, a modified rotenoid with an open ring-C, representing a new sub-class of isoflavonoids (the sub-class is here named as rotenoloid), was isolated and characterised. In addition, the known

[Isolation and identification of brine shrimp lethal activities from Derris trifoliata].

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OBJECTIVE To study the brine shrimp lethal activities of the roots and stems from Derris trifoliata. METHODS The biological activity of the athyl acetate extract was tested by the 2nd-instar of Artemia franciscana by the method of Silica gel column chromatography, Sephadex LH-20 column

A new prenylated flavanone from Derris trifoliata Lour.

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A new flavanone, 4',5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)- flavanone, was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro-rotenone, dehydrodeguelin, 7a-O-methyldeguelol,

Review article number 135 biosynthesis in the rotenoid group of natural products: applications of isotope methodology.

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Using the natural rotenoids rotenone, amorphigenin, deguelin, rotenonic acid, dalpanol and munduserone as examples, their phytochemical biosynthesis has been examined in Derris elliptica, Amorpha fruticosa and Tephrosia vogelii. The rotenoids are advanced isoflavonoids, and construction of their

[Modification of the analytical method for rotenoids in plants].

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Rotenoids are the active ingredients of some botanical insecticides and prospective candidates as anticancer agents. The proper isolation and determination of rotenoids in plants is of great importance for their further research and development. However, the HPLC method available for this purpose

Cancer chemopreventive activity of rotenoids from Derris trifoliata.

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A study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aalpha,12aalpha-12a-hydroxyelliptone ( 3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents

Cancer chemopreventive activity of rotenoids from Derris trifoliata.

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Nitric oxide inhibitory principles from Derris trifoliata stems.

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Nine rotenoids were isolated from the hexane and dichloromethane extracts of Derris trifoliata stems and were tested for nitric oxide (NO) inhibitory activity using RAW264.7 cells. The result indicated that 12a-hydroxyrotenone (7) possessed very potent NO inhibitory activity with an IC(50) value of

[Separation and preparation of two rotenoids from the roots of Derris by high-speed counter-current chromatography].

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Two rotenoids (rotenone and deguelin) were successfully isolated and purified from the roots of Derris by high-speed counter-current chromatography (HSCCC) with a two-phase solvent system composed of n-hexane-ethylacetate-methanol-water (7: 0. 25:5:3, v/v/v/v) on a preparative scale. The lower phase

Analysis and quantitation of rotenoids and flavonoids in Derris (Lonchocarpus urucu) by high-temperature high-resolution gas chromatography.

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A glass capillary column coated with PS-086 (15% phenyl-80% methylpolysiloxane, 15 m x 0.30-mm i.d., 0.1-microm film thickness) is used to analyze extracts from Lonchocarpus urucu (Derris urucu). Several secondary metabolites (8 flavonoids, 10 rotenoids) are characterized without derivatization, and

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