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endometrial hyperplasia/potasyòm
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HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium.
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HERG K(+)channels, besides contributing to regulate cardiac and neuronal excitability, are preferentially expressed in tumour cell lines of different histogenesis, where their role in the development and maintenance of the neoplastic phenotype is under study. We show here that both herg gene and
BKCa participates in E2 inducing endometrial adenocarcinoma by activating MEK/ERK pathway.
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BACKGROUND
The large-conductance, voltage-gated, calcium (Ca (2+))-activated potassium channel (BKCa) plays an important role in regulating Ca (2+) signaling and cell physiological function, and is aberrantly expressed in some types of cancers. The present study focuses on identifying the oncogenic
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