Regular intestinal lavage with normal saline twice per day, starting after randomization and not later than 24 hours of age, and continued until full enteral nutrition of 170ml/kg/day is achieved or NEC diagnosis (Bell stage II or more) is established, which one comes first. The intervention will be applied at a maximum of 2 weeks from birth.

Current routine for extremely preterm infants that do not defecate adequately will be applied.

Necrotizing Enterocolitis

Time to Full Enteral Nutrition

Specially trained pediatric surgeon will administer 10ml/kg pre-warmed (37oC) normal saline via a single-use rectal tube of size 6FR twice per day, aiming at a depth of maximum 10 cm/kg, starting after randomization and not later than 24 hours of age, and continued until full enteral nutrition of 170ml/kg/day is achieved or NEC diagnosis (Bell stage II or more) is established, which one comes first. However, the intervention will be applied at a maximum of 2 weeks from birth.

Intestinal lavage with normal saline

Neonatal intensiv care unit, 95F, Akademiska hospital

Intestinal Lavage to Promote Enteral Feeding and Prevent Necrotizing Enterocolitis in Extremely Preterm Infants

Regular Intestinal Lavage to Promote Enteral Feeding and Prevent Necrotizing Enterocolitis in Extremely Preterm Infants. A Randomized Controlled Trial Protocol

The time period between birth and achievement of enteral nutrition of 170ml/kg/d (days)

According to the International Classification of ROP (Arch Ophthalmol. 2005)

According to NICHD/NHLBI/ORD guidelines (Am J Respir Crit Care Med. 2001)

The time period between birth and regaining of BW (days)

Age of the child at the time of hospital discharge (days)

Assessed according to the national program for follow up of extremely preterm infants in Sweden. Assessments include examination by neonatologist, pediatric neurologist, psychologist, physiotherapist, audiologist, opthalmologist, at prespecified intervals until the age of 5,5 years

Maximum serum level of unconjugated and conjugated bilirubin (μmol/L)

Spyridon Gialamas

MD, PhD

Uppsala County Council, Sweden

Colonic Diseases

description of the results of colonoscopy im managment of children with rectal bleeding

colonoscopy

Ting wu C, Chen C. Characteristics and diagnostic yield of pediatric colonoscopy in Taiwan, Pediatric of neonatology 2015; 56(5): 334-8

Tringali A,Balassone V,Angelis P.Complication in pediatric colonoscopy.2015;30(5):825-39.

Assiut U

Yield of Colonoscopy in Children With Rectal Bleeding

Yield of Colonoscopy in Children With Bleeding Per Rectum Attending Gastrointestinal Endoscopic Unit In Assuit University Children Hospital

Number of participants were monitored with recurrance of rectal bleeding and underwent colonoscopy up to 2 years

SHIraqi

principle investigator

Assiut University

Treat the patients by fecal microbiota transplantation

Methicillin-Resistant Staphylococcus Aureus

bacteria liquid from 60g fecal was infusion via nasointestinal tube for three days

Fecal microbiota transplantation

Department of General Surgery, Jinling hosptal,Medical School of Nanjing University

Biotherapy for MRSA Enterocolitis

Fecal Microbiota Transplantation Restores Dysbiosis in Patients With Methicillin Resistant Staphylococcus Aureus Enterocolitis

weiyao

Institute of General Surgery

Jinling Hospital, China

Breast Cancer

Bone Metastasis

Pain

chemoradiation

Rabin Medical Center, Beilinson Campus

Chemoradiation for Bone Metastasis

Chemoradiation With Capecitabine for Palliation of Pain From Bone Metastasis

Patients were asked to score their pain on a scale of 0 (no pain) to 10 (worst possible pain) before treatment and at 1, 2, 4, 8 and 12 weeks after treatment initiation.

Consumption of analgesics was evaluated by the physician using the 5-point WHO score, as follows: level 0, no analgesics required; level 1, non-narcotic analgesics required occasionally; level 2, non-narcotic analgesics required regularly; level 3, narcotic analgesics required occasionally; level 4, narcotic analgesics required regularly

Rabin Medical Center

Sheba Medical Center

Labor, Premature

Arm A:
Nifedipine 20 mg sublingual, repeated after 30 minutes if contractions do not decrease in intensity. Maintenance of 120-160 mgs of slow-release nifedipine daily for 48 hours.Once contractions cease, nifedipine will be maintained at 80-120 mg daily in divided doses up to 36 weeks.
Arm B:
Nifedipine 10 mg sublingual crushed, then 10 mg in 15 min, followed by 10 mg PO Q 15 mins PRN to a maximum of 40 mg in the first hour. Maintenance of 60-80 mgs of slow-release nifedipine daily for 48 hours. Once contractions cease, nifedipine will be maintained at 60 mg daily in divided doses up to 36 weeks.

enterocolitis/nausea

Intestinal Lavage to Promote Enteral Feeding and Prevent Necrotizing Enterocolitis in Extremely Preterm Infants

Yield of Colonoscopy in Children With Rectal Bleeding

Biotherapy for MRSA Enterocolitis

Chemoradiation for Bone Metastasis

Two Dose Regimens of Nifedipine for the Management of Preterm Labor

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