forskolin/fatigue

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Pharmacological evidence for the involvement of the cAMP cascade in sensory fatigue in Drosophila.

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We have investigated the effect of systemic treatment with drugs that affect the cAMP cascade on the sensory response and sensory fatigue in an identified mechanosensory neuron of Drosophila. Forskolin, an activator of adenylate cyclase, decreases the sensory response of the neuron. H7, an inhibitor

Promotion of forskolin-induced long-term potentiation of synaptic transmission by caffeine in area CA1 of the rat hippocampus.

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Caffeine which is present in soft drinks has been shown to increase alertness and allays drowsiness and fatigue. The aim of this study is to investigate whether caffeine could produce a long-term effect on the synaptic transmission using extracellular recording technique in the hippocampal slices.

Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus.

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Although recent studies indicate that brain-derived neurotrophic factor (BDNF) plays an important role in hippocampal synaptic plasticity, the underlying signaling mechanisms remain largely unknown. Here, we have characterized the signaling events that mediate the BDNF modulation of high-frequency

The effect of inhaled colforsin daropate on contractility of fatigued diaphragm in dogs.

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We studied the effect of inhaled colforsin daropate, a water-soluble forskolin derivative, on the contractility of fatigued diaphragm in dogs. Animals were divided into 3 groups of 8. In each group, diaphragmatic fatigue was induced by intermittent supramaximal bilateral electrophrenic stimulation

Plectranthus barbatus: a review of phytochemistry, ethnobotanical uses and pharmacology - part 2.

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Plectranthus barbatus andr. is one of the most important species of the genus Plectranthus L' Herit. (Lamiaceae), with a wide variety of traditional medicinal uses in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China. The plant has

Recovery of free muscle grafts in rat: improvement is associated with an increase in cyclic adenosine monophosphate concentration or use of the condition/test paradigm.

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The muscle fibers in freely grafted skeletal muscles degenerate and are replaced by new fibers which develop within the graft. Myogenesis in regenerating muscle recapitulates, to a large extent, developmental myogenesis and may depend on similar modulating influences. In addition to the generation

Plectranthus barbatus: a review of phytochemistry, ethnobotanical uses and pharmacology - Part 1.

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Plectranthus barbatus Andr. is one of the most important species of the genus Plectranthus L' Herit. (Lamiaceae), with a wide variety of traditional medicinal uses in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China. The plant has

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