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fraxinus syriaca/triglyceride
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Esculin improves dyslipidemia, inflammation and renal damage in streptozotocin-induced diabetic rats.
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BACKGROUND
Increasing studies have shown that dyslipidemia and inflammatory responses play important roles in the progression of microvascular diabetic complications. Esculin (ES), a coumarin derivative, was extracted from Fraxinus rhynchophylla. The present study was to evaluate the potential
Hydroxyframoside B, a secoiridoid of Fraxinus rhynchophylla, inhibits adipocyte differentiation in 3T3-L1 cells.
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Fraxinus rhynchophylla showed significant inhibitory activity on adipocyte differentiation in the 3T3-L1 preadipocyte cell line as assessed by measuring fat accumulation using Oil Red O staining. Further fractionation led to the isolation of two secoiridoids, oleuropein and hydroxyframoside B.
Effect of pregnenolone-16alpha-carbonitrile on the rat liver.
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In female rats, pregnenolone-16alpha-carbonitrile [PCN (a known microsomal enzyme inducer)] augmented liver weight and significantly increased hepatic protein, total lipid, phospholipid and ATP concentrations. These changes were correlated with hepatic drug-metabolizing enzyme induction. PCN did not
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