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guaianolide/tibèkiloz
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Sesquiterpene lactones from the leaves of Hedyosmum brasiliense (Chloranthaceae).
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Hedyosmum brasiliense Miq. is an endemic aromatic arborescent shrub that is the only representative of the Chloranthaceae in Brazil. There have been few studies seeking to determine its chemical constituents and/or pharmacological effects. This work describes the isolation and identification of
Antimycobacterial activities of dehydrocostus lactone and its oxidation products.
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In an attempt to study the structural dependence of antimycobacterial activity of the guaianolide dehydrocostus lactone and its derivatives, m-chloroperoxybenzoic acid oxidations of dehydrocostus lactone (1a) were performed. Three new monoepoxides, one previously synthesized diepoxide, and two new
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