heliotrine/leukemia

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Relationship of the reductive metabolism of indicine N-oxide to its antitumor activity.

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Several pyrrolizidine alkaloids have been demonstrated to have antitumor activity in experimental tumor systems. In general the free base form of the alkaloid exhibits greater biological activity than the corresponding N-oxide and the N-oxide must be metabolized to the base for the subsequent

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Herbal & Natural Medicine

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