Systemic Inflammatory Response Syndrome

Bolus injection of LPS 2 ng/kg IV at time = 2 hours (Study day A).

Endotoxin

Transdermal application of nicotine patch applied at time = -8 hours (midnight the day before Study day B) + bolus injection of LPS 2 ng/kg at time = 2 hours (Study day 2)

Endotoxin + Nicotine

Center for Inflammation and Metabolism, Rigshospitalet

Autonomic Nervous Activity During the Systemic Inflammatory Response in Trained and Untrained Healthy Volunteers

Cytokines are released into the bloodstream as part of the systemic inflammatory response and allow quantification of the severity of the systemic inflammatory response.
Cytokines are measured multiple times to record changes from baseline during the intervention.

HRV is the variation in the interval between heart beats over a given time period. A higher variability is considered an indirectly marker of increasing vagal acitivity. Low variability contrarily indicates decreasing vagal activity and increased sympathetic activity.
HRV is calculated from continous, non-invasive monitoring of heart rhytm. Recordings are made at multiple fixed times to track changes from baseline during intervention.

Pressure algometry performed by a hand-held device with a tip area of 1 cm2 applied perpendicularly on the non-dominant lateral vastus muscle with a gradual increase in pressure until participant indicates painful stimuli.

A sequence of 4 tonic heat stimuli (45, 46, 47 and 48°C) delivered by a thermos with a duration of 5 s each and separated by an interstimulus interval of 30 s. Participants rated pain sensation using a visual analog scale (VAS).

hypocapnia/necrosis

Autonomic Nervous Activity During the Systemic Inflammatory Response in Trained and Untrained Healthy Volunteers

Baz done ki pi konplè remèd fèy medsin te apiye nan syans