whey protein powder was added on the basis of standardized enteral nutrition preparation.

standardized enteral nutrition preparation only.

Nutrition Disorders

Neurologic Disorder

whey protein

Xuanwu Hospital

The Effects of Enteral Whey Protein Supplement on Serum Albumin Level in Acute Critically Ill Neurological Patients

such as gastric retention, vomiting, diarrhea, abdominal distention, constipation and gastrointestinal bleeding

Xuanwu Hospital, Beijing

Severe patients with bloodstream infections often have sepsis / septic shock, acute kidney injury (AKI), chronic kidney disease (CKD), hypoproteinemia, and blood purification treatment.

Take blood and urine samples at several time points before and after daptomycin administration, and measure the blood and urine concentrations of the patient

Outcome, Fatal

Infection

Adult patients are given the recommended dose of daptomycin for injection. Patients with creatinine clearance (CLCR) ≥ 30 mL / min: 6 mg / kg every 24 hours.
Patients with creatinine clearance (CLCR) <30mL / min (including hemodialysis or peritoneal dialysis): 6mg / kg every 48 hours. Dissolve 6mg / kg of this drug in 0.9% sodium chloride injection and instill it over a 30-minute time course once every 24 or 48 hours.

Daptomycin

Zhongnan Hospital of Wuhan University

Factors of Pharmacokinetics/Pharmacodynamics of Daptomycin in Critical Ill Patients and Effects of Daptomycin on Kidney

The Influence Factors of Pharmacokinetics/Pharmacodynamics of Daptomycin in Severe Patients and the the Effect of Different Blood Concentration of Daptomycin on the Outcomes of Renal Function

Apparent volume of distribution of daptomycin in the patient's blood

Plasma trough concentration of daptomycin

Area under the plasma concentration versus time curve (AUC) of daptomycin

Daptomycin is metabolized mainly by the kidneys

Reversible binding of daptomycin to plasma proteins (mainly serum albumin)

Serum creatinine can reflect kidney function

Major Adverse kidney Event（MAKE）Refers to death, need for renal replacement therapy, and creatinine levels that are twice or more the baseline value；It can reflects the outcome of renal function.

Reflect the severity of the patient's infection

ZhiYong Peng

Professor; Chief physician

Zhongnan Hospital

Very Preterm Infants

Patient inclusion at birth
Total plasma protein values measurement on cord blood sample at birth
Hemodynamic evaluation at 6 hours after birth with colour doppler echocardiography and organ blood flow colour doppler
Total plasma protein and albumin values measurement on plasma sample at 12 hours after birth
Blood pressure, heart rate, O2 saturation, capillary refill time, rSO2 [regional (cerebral and somatic) tissue oxygenation by NIRS - near infrared spectroscopy] will be monitored over 24 hours after birth.

Evaluation of the relationship plasma protein levels - neonatal hemodynamics

Centre Hopsitalier Universitaire de La Réunion

Centre Hospitalier de La Réunion

Plasma Protein Levels and Very Preterm Birth

Early Plasma Protein Levels and Neonatal Hemodynamics: a Prospective Evaluation in Very Preterm Infants

plasma protein level on cord blood sample depending on maternal and neonatal variables

Centre Hospitalier Universitaire de la Réunion

INSERM CIE1, Dijon, 21000, France

Investigational drug: HES 130/0.4 (6%) in sodium chloride (Voluven®, solution for infusion)

Control drug: Human serum albumin (HSA 50g/L)

6% Hydroxyethylstarch 130/0.4, i.v. Voluven® rates were not to exceed 50 mL/kg/day; if additional study drug was required, 5% HSA was provided as rescue colloid.

Voluven® Arm

HSA 5% Arm (Comparison Group)

Total

Sex: Female, Male

Region of Enrollment

Weight

Height

Total volume of study drug plus rescue colloid, if applicable

Total Volume of Colloid Solution Required Intraoperatively

Mean arterial pressure (MAP) from beginning of anaesthesia (baseline) until arrival on intensive care unit (ICU)

Mean Arterial Pressure (MAP)

Quantity of total fluids administered from beginning of anaesthesia until 2nd postop morning

Fluid Input

Quantity of total fluids excreted or lost from beginning of anaesthesia until 2nd postop morning

Fluid Output

Balance of total fluid input and total fluid output

Fluid Balance

Calculated perioperative RBC loss = Predicted blood volume1 × (hematocrit [baseline] - hematocrit [2nd postop morning]) + transfused RBC volume2;
Predicted blood volume (mL) = 80 × body weight (kg)
Transfused RBC volume = 0.7 × infused packed RBC

Calculated Perioperative Red Blood Cell (RBC) Loss

Length of stay (number of days) on the intensive care unit (ICU).

Length of Stay on the Intensive Care Unit (ICU)

Mortality was reported for the time period from screening until the end of follow-up.

Mortality

Acute renal failure was defined as a two fold increase in serum creatinine concentration over the value at baseline at any time after baseline.

Acute Renal Failure (ARF)

Overall Study

Professor Dr. Martin Westphal, Chief Medical Officer

Cardiac Surgery

Cardiopulmonary Bypass

Study medication will be given as part of the priming of the ECC and for plasma volume replacement after start of ECC up to the maximum dosage of 50 mL/kg body weight/day.

HES 130/0.4 (6%) in sodium chloride (Voluven®, solution for infusion), Human serum albumin (HSA 50g/L)

Human serum albumin (HSA 50g/L)

AKh Allgemeines Krankenhaus der Stadt Linz GmbH

HUDERF - Hôpital Universitaire des Enfants Reine Fabiola

Voluven® in Paediatric Patients

Efficacy and Safety of 6 % Hydroxyethyl Starch 130/0.4 (Voluven®) vs. 5% HSA in Volume Replacement Therapy During Elective Open-heart Surgery in Paediatric Patients

hypoproteinemia/albumin

The Effects of Enteral Whey Protein Supplement on Serum Albumin Level in Acute Critically Ill Neurological Patients

Factors of Pharmacokinetics/Pharmacodynamics of Daptomycin in Critical Ill Patients and Effects of Daptomycin on Kidney

Plasma Protein Levels and Very Preterm Birth

Voluven® in Paediatric Patients

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